Lioresal

Baclofen, the active ingredient in Lioresal, is a GABA_B receptor agonist presented as a tablet for oral use. It reduces muscle spasticity by modulating central nervous system pathways and is indicated for patients with multiple sclerosis, spinal cord injury, cerebral palsy, and other disorders that cause increased muscle tone.

GNH USA supplies Lioresal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution.

Baclofen is used to manage spasticity arising from central nervous system disorders.

Multiple sclerosis spasticity: Reduces muscle tone and improves mobility. Spinal cord injury spasticity: Decreases hypertonia and facilitates physiotherapy. Cerebral palsy spasticity: Relieves muscle stiffness and enhances functional movement. Other CNS‑related hypertonia: Lowers excessive muscle contraction in various neurological conditions.

Baclofen may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects: - Dizziness - Drowsiness or fatigue - Weakness - Nausea - Headache - Dry mouth

Serious or Rare Side Effects: - Seizures - Hallucinations or psychosis - Severe hypotension - Respiratory depression - Allergic reactions (rash, swelling) - Urinary retention

Before initiating therapy, consider the following precautions.

Renal impairment: Adjust dose or monitor closely. Hepatic dysfunction: Use with caution and monitor liver function. Concomitant CNS depressants: Increased risk of sedation and respiratory depression. Abrupt discontinuation: May precipitate withdrawal symptoms such as agitation or hallucinations. Pregnancy: Use only if the potential benefit justifies the potential risk to the fetus. Store at ambient temperature: Keep in the original packaging, protect from moisture and heat.

Baclofen can interact with several medicines; awareness helps avoid complications.

Major Interactions (Avoid): - Opioids: Additive central nervous system depression. - Antihistamines: Heightened sedation. - Alcohol: Enhanced drowsiness and impaired coordination. - Anticonvulsants: May reduce baclofen's efficacy.

Moderate Interactions (Monitor Closely): - CYP450 inhibitors: Potential increase in baclofen plasma levels. - Diuretics: May augment hypotensive effects. - Tricyclic antidepressants: Monitor for increased sedation.