GNH USA

Europe — EMA

Lioresal

GNH USA supplies Lioresal (Baclofen), an antispasmodic for spasticity due to MS, spinal cord injury or cerebral palsy. Request a quote for global supply.

Baclofen

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What is Baclofen?

Baclofen, the active ingredient in Lioresal, is a muscle relaxant presented as an oral tablet for oral use. It treats spasticity associated with multiple sclerosis, spinal cord injury and cerebral palsy. GNH USA supplies Lioresal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Baclofen used for?

Baclofen acts on the central nervous system to reduce muscle tone in conditions characterized by spasticity. - Multiple sclerosis‑related spasticity: decreases muscle stiffness and improves mobility. - Spinal cord injury‑related spasticity: lessens involuntary muscle contractions and facilitates functional movement. - Cerebral palsy‑related spasticity: reduces hypertonia and aids in rehabilitation efforts.

What are the side effects of Baclofen?

Baclofen may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Dizziness - Drowsiness or fatigue - Weakness - Nausea or upset stomach - Headache - Dry mouth

Serious or Rare Side Effects: - Seizures - Hallucinations or psychosis - Severe hypotension - Respiratory depression - Allergic reactions such as rash or angioedema - Cardiac arrhythmias

What precautions apply to Baclofen?

When prescribing baclofen, clinicians should consider several safety factors. - Renal impairment: adjust dose under medical supervision. - Hepatic impairment: monitor closely for accumulation. - Concomitant CNS depressants: increased risk of sedation and respiratory depression. - Abrupt discontinuation: may cause withdrawal symptoms; taper gradually. - Pregnancy: safety not established; use only if benefit outweighs risk. - Store at room temperature: keep in original container, protect from moisture and light.

What does Baclofen interact with?

Baclofen can interact with other medicines, requiring attention to avoid harmful effects.

Major Interactions (Avoid): - Alcohol: potentiates central nervous system depression. - Opioids: increased risk of respiratory depression. - Carbamazepine or other enzyme inducers: may reduce baclofen plasma levels.

Moderate Interactions (Monitor Closely): - Antihypertensives: additive hypotensive effect. - CYP450 inhibitors (e.g., erythromycin): may raise baclofen concentrations. - Diuretics: can enhance hypotension and electrolyte disturbances.

Frequently asked questions

What conditions is Lioresal used to treat?+
Lioresal, containing baclofen, is prescribed to manage muscle spasticity that occurs in multiple sclerosis, spinal cord injury and cerebral palsy. By reducing excessive muscle tone, it helps improve mobility and ease of movement for patients with these neurological disorders.
How does baclofen work to relieve spasticity?+
Baclofen binds to GABA_B receptors in the spinal cord, which inhibits the release of excitatory neurotransmitters. This action dampens the reflex arcs that cause involuntary muscle contraction, leading to a reduction in spasticity and improved muscle control.
What is the usual dose of Lioresal?+
The appropriate dose of Lioresal is determined by the prescribing clinician based on the individual’s medical condition, response to therapy and any co‑existing health issues. Dosage titration is typically started low and increased gradually under medical supervision.
Is Lioresal safe to use during pregnancy or breastfeeding?+
Safety data for baclofen in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and this decision must be made by a qualified health professional.
How do I order Lioresal from GNH USA?+
To request Lioresal, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Lioresal compare with other antispasmodic drugs?+
Lioresal (baclofen) is a GABA_B receptor agonist, whereas other antispasmodics such as tizanidine act on α2‑adrenergic receptors. Baclofen’s mechanism provides a direct reduction of spinal reflex activity, often resulting in a distinct side‑effect profile and dosing considerations compared with alternatives.
What are the recommended storage conditions for Lioresal?+
Lioresal should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and excessive heat to maintain its stability and potency.
How is Lioresal administered to patients?+
Lioresal is taken orally, usually in tablet form, with or without food as directed by the prescriber. The exact timing and frequency depend on the individualized dosing regimen established by the treating physician.
What are the most serious risks associated with Lioresal?+
Serious risks include seizures, severe hypotension, respiratory depression, hallucinations or other neuropsychiatric events, and allergic reactions such as rash or angioedema. Patients should be monitored closely for any of these symptoms, especially during dose adjustments.
Who should not use Lioresal?+
Lioresal is contraindicated in individuals with known hypersensitivity to baclofen or any of its excipients. Caution is also advised for patients with severe renal or hepatic impairment, uncontrolled epilepsy, or those taking other central nervous system depressants without proper medical oversight.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Baclofen
Route
Oral Use
Manufacturer
Novartis Ireland Limited
Origin
EU

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