Lioresal

Baclofen, the active ingredient in Lioresal, is a central muscle relaxant presented as a tablet for oral use. It treats muscle spasticity associated with multiple sclerosis, spinal cord injury, cerebral palsy, and other conditions that cause muscle spasms.

GNH USA supplies Lioresal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution. Customers benefit from consistent product availability, regulatory compliance, and dedicated technical support throughout the supply chain.

Lioresal (baclofen) is used to manage spasticity and related muscle tone disorders across several neurological conditions.

- Multiple sclerosis spasticity: reduces muscle tone and improves mobility in patients with MS‑related spasticity. - Spinal cord injury spasticity: decreases involuntary muscle contractions, facilitating functional movement and comfort. - Cerebral palsy spasticity: lessens stiffness and enhances range of motion for individuals with CP‑related muscle tightness.

Baclofen may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects: - Dizziness - Drowsiness - Nausea - Weakness

Serious or Rare Side Effects: - Seizures - Hallucinations - Severe hypotension - Respiratory depression

When prescribing baclofen, clinicians should consider several precautionary measures to ensure safe use.

- Renal impairment: dose may need adjustment and renal function should be monitored. - Hepatic impairment: use with caution and monitor liver enzymes. - Concomitant CNS depressants: increased risk of sedation and respiratory depression. - Abrupt discontinuation: may precipitate withdrawal symptoms such as agitation or hallucinations. - Pregnancy and lactation: safety not established; weigh potential benefits against risks. - Store at ambient temperature: keep in the original pack, protect from moisture.

Baclofen can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid): - Alcohol: additive CNS depression may cause profound sedation. - Strong CNS depressants (e.g., opioids, benzodiazepines): risk of respiratory depression and excessive sedation.

Moderate Interactions (Monitor Closely): - Antihypertensive agents: baclofen may enhance blood‑pressure‑lowering effects. - CYP450 inhibitors (e.g., cimetidine): may increase baclofen plasma concentrations. - Anticonvulsants (e.g., carbamazepine): may reduce baclofen effectiveness.