Lioresal

Baclofen, the active ingredient in Lioresal, is a GABA_B receptor agonist presented as an oral tablet for oral use. It is employed to reduce muscle spasticity associated with neurological conditions such as multiple sclerosis, spinal cord injury and cerebral palsy. By activating GABA_B receptors in the spinal cord, it inhibits reflex arcs that generate excessive muscle tone.

GNH USA supplies Lioresal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for global healthcare providers.

Lioresal (baclofen) acts on the GABA_B pathway to manage spasticity in several neurological disorders.

- Multiple sclerosis spasticity: reduces muscle tone and improves mobility in patients with MS‑related spasticity. - Spinal cord injury spasticity: decreases involuntary muscle contractions and facilitates functional movement after spinal cord injury. - Cerebral palsy spasticity: lessens stiffness and enhances motor control in individuals with cerebral palsy.

Baclofen may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Dizziness - Drowsiness - Nausea - Weakness

Serious or Rare Side Effects: - Seizures - Respiratory depression - Allergic reactions (rash, angioedema)

When prescribing baclofen, clinicians should consider several precautionary measures to ensure safe use.

- Assess renal function: dose adjustment may be required in patients with impaired renal clearance. - Monitor for withdrawal: abrupt discontinuation can lead to rebound spasticity and seizures. - Evaluate CNS disorders: use cautiously in patients with a history of depression or epilepsy. - Review concomitant CNS depressants: combined use may enhance sedation and respiratory effects. - Pregnancy and lactation: safety has not been established; weigh potential risks and benefits. - Store at ambient temperature: keep below 25 °C in the original packaging, protected from moisture.

Baclofen can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid): - Opioids: combined CNS depression may cause profound sedation or respiratory compromise. - Antihypertensives: additive hypotensive effect may lead to marked blood pressure drops. - Alcohol: enhances sedative properties and impairs coordination.

Moderate Interactions (Monitor Closely): - Anticonvulsants (e.g., carbamazepine): may reduce baclofen plasma levels. - CNS stimulants (e.g., caffeine): may counteract baclofen’s sedative effect.