GNH USA

Europe — EMA

Lioresal

GNH USA supplies Lioresal (Baclofen), a muscle relaxant for spasticity in multiple sclerosis, spinal cord injury and cerebral palsy. Request quote for supply.

Baclofen

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What is Baclofen?

Baclofen, the active ingredient in Lioresal, is a muscle relaxant presented as a tablet for oral use. It treats muscle spasticity associated with multiple sclerosis, spinal cord injury, cerebral palsy, and other conditions that cause involuntary muscle contractions. It is indicated for patients who experience increased muscle tone that interferes with daily activities and mobility.

GNH USA supplies Lioresal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to Good Distribution Practice standards and provides regulatory‑compliant sourcing for global healthcare providers.

What is Baclofen used for?

Lioresal (baclofen) acts on the central nervous system to reduce abnormal muscle tone in several neurologic conditions.

Multiple sclerosis spasticity: reduces muscle tone and improves mobility. Spinal cord injury spasticity: decreases involuntary muscle contractions and facilitates rehabilitation. Cerebral palsy spasticity: lessens stiffness, aiding functional movement. Muscle spasm: provides relief from acute muscle cramps and tightness.

What are the side effects of Baclofen?

Baclofen may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Drowsiness - Dizziness - Weakness - Nausea

Serious or Rare Side Effects: - Seizures - Hallucinations - Respiratory depression - Severe allergic reactions

What precautions apply to Baclofen?

When prescribing Lioresal, clinicians should consider several safety factors.

Renal impairment: adjust dose and monitor renal function. Hepatic impairment: use with caution and consider dose reduction. Concomitant CNS depressants: increased risk of sedation and respiratory depression. Abrupt discontinuation: taper dose to avoid withdrawal symptoms. Pregnancy: category C, weigh potential benefits against risks. Store at ambient temperature: keep in original container, protect from moisture and heat.

What does Baclofen interact with?

Baclofen can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid): - Alcohol or other CNS depressants: may cause profound sedation and respiratory depression. - Benzodiazepines: additive central nervous system depression. - Opioids: increased risk of respiratory depression and sedation.

Moderate Interactions (Monitor Closely): - Antihypertensive agents: baclofen may enhance hypotensive effect. - CYP450 inhibitors (e.g., cimetidine, erythromycin): may increase baclofen plasma levels.

Frequently asked questions

What is Lioresal used for?+
Lioresal is the brand name for the oral tablet containing baclofen, a prescription muscle relaxant. It is primarily used to manage spasticity—abnormally increased muscle tone—in conditions such as multiple sclerosis, spinal cord injury, cerebral palsy, and other disorders that cause involuntary muscle contractions. By reducing muscle stiffness, it helps improve mobility and daily functioning.
How does baclofen work?+
Baclofen works by stimulating GABA_B receptors in the spinal cord and brainstem. Activation of these receptors inhibits the release of excitatory neurotransmitters, decreasing neuronal firing and reducing the reflex pathways that cause muscle over‑activity. This central nervous system effect leads to a dose‑dependent reduction in muscle tone and spasticity, facilitating smoother movement.
What is the usual dose?+
The appropriate dose of Lioresal is individualized by a qualified prescriber based on the patient’s condition, response, and tolerability. Typically, treatment begins with a low dose that is gradually increased at regular intervals until the desired therapeutic effect is achieved while minimizing side effects. Patients should follow the dosing schedule provided by their healthcare professional.
Is it safe in pregnancy or breastfeeding?+
Baclofen is classified as pregnancy category C, indicating that risk to the fetus cannot be ruled out and the drug should only be used when the potential benefit justifies the potential risk. Limited data are available for breastfeeding, and baclofen does pass into breast milk; therefore, a healthcare professional should evaluate the risk‑benefit balance before use.
How do I order Lioresal from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity of Lioresal. GNH USA works with hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the sales team provides pricing, availability, shipping details and any necessary import documentation.
How does Lioresal compare with the main alternative drug or class?+
The most common alternative to baclofen is tizanidine, another centrally acting muscle relaxant. Both reduce spasticity, but baclofen primarily targets GABA_B receptors, whereas tizanidine acts on α2‑adrenergic receptors. Baclofen has a longer half‑life and is often preferred for chronic management, while tizanidine may cause more pronounced dry mouth and hypotension. Choice depends on individual response and tolerability.
How should Lioresal be stored and handled?+
Lioresal tablets should be stored at ambient temperature, below 25 °C, in their original blister pack to protect them from moisture and light. Keep the medication out of reach of children and do not use if the packaging is damaged. No special refrigeration is required for this oral formulation.
How is Lioresal administered?+
Lioresal is taken orally as a tablet, usually with a full glass of water. It may be taken with or without food, but consistent timing with respect to meals can help maintain steady drug levels. Patients should swallow the tablet whole and avoid crushing or chewing it unless instructed otherwise by a healthcare professional.
What are the most serious risks to watch for?+
Although uncommon, serious adverse events can occur with baclofen. Patients should be alert for signs of seizures, severe respiratory depression, marked hypotension, hallucinations, or allergic reactions such as rash, swelling, or difficulty breathing. Any of these symptoms require immediate medical attention and possible discontinuation of therapy.
Who should not use Lioresal?+
Lioresal is contraindicated in individuals with known hypersensitivity to baclofen or any tablet excipients. It should be used with caution, or avoided, in patients with severe renal or hepatic impairment, uncontrolled epilepsy, or those taking high‑dose CNS depressants. Pregnant women, nursing mothers, and children should only use the drug when clearly indicated by a physician.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Baclofen
Route
Oral Use
Manufacturer
Novartis Pharma N.V.
Origin
EU

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