GNH USA

Europe — EMA

Lioresal

GNH USA supplies Lioresal (Baclofen), a muscle relaxant for spasticity in MS, spinal cord injury and muscle spasms. Request a quote for global supply.

Baclofen

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What is Baclofen?

Baclofen, the active ingredient in Lioresal, is a muscle relaxant presented as an oral tablet for oral use. It is indicated for the management of spasticity associated with multiple sclerosis, spinal cord injury, and other muscle spasm conditions. GNH USA supplies Lioresal as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Baclofen used for?

Lioresal (baclofen) acts on the central nervous system to reduce abnormal muscle tone in several neurologic conditions.

Multiple sclerosis spasticity: reduces muscle stiffness and improves mobility. Spinal cord injury spasticity: alleviates involuntary muscle contractions. Muscle spasm: provides relief from acute muscle tightness.

What are the side effects of Baclofen?

Adverse reactions may occur with baclofen therapy.

Common Side Effects: - Dizziness - Drowsiness or fatigue - Weakness or muscle fatigue - Nausea or gastrointestinal upset - Headache - Dry mouth

Serious or Rare Side Effects: - Seizures - Hallucinations or psychosis - Severe hypotension - Respiratory depression - Allergic reactions (rash, swelling, anaphylaxis) - Urinary retention or difficulty voiding

What precautions apply to Baclofen?

Before initiating baclofen, consider the following safety measures.

Renal impairment: adjust dose and monitor renal function. Hepatic disease: use with caution and monitor liver enzymes. History of seizures: assess risk and titrate slowly. Concurrent CNS depressants: avoid additive sedation. Pregnancy: risk unknown; discuss benefits and risks with a healthcare professional. Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

What does Baclofen interact with?

Baclofen may interact with other medications; review patient medication lists.

Major Interactions (Avoid): - Alcohol: increased central nervous system depression. - Opioids: additive respiratory depression and profound sedation. - General anesthetics: may potentiate muscle weakness.

Moderate Interactions (Monitor Closely): - Antihypertensives: possible enhancement of hypotensive effect. - Anticonvulsants (e.g., carbamazepine): may reduce baclofen plasma levels.

Frequently asked questions

What conditions is Lioresal used to treat?+
Lioresal contains baclofen, which is prescribed to manage spasticity caused by multiple sclerosis, spinal cord injury, and other conditions that produce muscle spasms. It helps reduce abnormal muscle tone and improve functional movement in affected patients.
How does baclofen work to reduce spasticity?+
Baclofen acts as an agonist at GABA_B receptors in the spinal cord. Activation of these receptors inhibits the release of excitatory neurotransmitters, decreasing neuronal firing rates and leading to a reduction in muscle hypertonicity and spasticity.
What is the usual dose of Lioresal?+
The dosage of Lioresal is individualized. A prescriber determines the appropriate starting dose and titration schedule based on the patient’s condition, response, and tolerability. Patients should follow the prescribing clinician’s instructions and not adjust the dose on their own.
Is Lioresal safe to use during pregnancy or breastfeeding?+
Safety data for baclofen in pregnancy and lactation are limited. Healthcare providers should weigh potential benefits against possible risks and discuss them with the patient. If prescribed, the drug should be used only when clearly needed and under medical supervision.
How do I order Lioresal from GNH USA?+
To request Lioresal, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Lioresal compare with other antispastic agents?+
Baclofen is a GABA_B agonist, whereas other antispastic drugs such as tizanidine act on α2‑adrenergic receptors. Baclofen’s mechanism provides a direct reduction of excitatory neurotransmission in the spinal cord, often resulting in a predictable dose‑response profile, but individual response and side‑effect tolerance may differ.
What are the recommended storage conditions for Lioresal?+
Lioresal should be stored at room temperature, below 25 °C. Keep the tablets in the original packaging, protect them from moisture, heat, and direct sunlight to maintain product stability throughout its shelf life.
How is Lioresal administered?+
Lioresal is taken orally, usually as a tablet. It is swallowed with water and can be taken with or without food, depending on the prescriber’s guidance. Doses are typically started low and increased gradually to achieve the desired therapeutic effect.
What are the most serious risks associated with Lioresal?+
Serious risks include seizures, severe hypotension, respiratory depression, and rare allergic reactions such as anaphylaxis. Patients should be monitored for these events, especially when initiating therapy, adjusting doses, or combining baclofen with other central nervous system depressants.
Who should not use Lioresal?+
Lioresal is contraindicated in individuals with known hypersensitivity to baclofen or any of its excipients. Caution is advised for patients with severe renal or hepatic impairment, uncontrolled epilepsy, or those taking other potent CNS depressants, unless a healthcare professional determines it is safe.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Baclofen
Route
Oral Use
Manufacturer
Novartis Pharma Gmbh
Origin
EU

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