Lionova

Baclofen, the active ingredient in Lionova, is a GABA_B receptor agonist presented as a intrathecal solution for intrathecal use. It treats spasticity associated with multiple sclerosis, spinal cord injury, and cerebral palsy, helping to reduce muscle tone and improve functional mobility.

GNH USA supplies Lionova as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, clinics and transplant centres worldwide.

Baclofen is used to manage spasticity disorders affecting the central nervous system.

- Multiple sclerosis‑related spasticity: reduces muscle tone and improves mobility for patients with MS. - Spinal cord injury‑related spasticity: decreases involuntary muscle contractions and facilitates rehabilitation. - Cerebral palsy‑related spasticity: helps control muscle stiffness and supports physiotherapy outcomes.

Baclofen may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Dizziness: sensation of light‑headedness or unsteadiness. - Fatigue: generalized tiredness or reduced energy. - Nausea: feeling of queasiness, sometimes with vomiting. - Headache: mild to moderate cranial pain. - Hypotension: lowered blood pressure, may cause faintness. - Constipation: reduced bowel movements.

Serious or Rare Side Effects: - Respiratory depression: marked reduction in breathing effort. - Severe hypotension: significant drop in blood pressure requiring medical attention. - Seizures: occurrence of convulsive episodes. - Allergic reactions: rash, itching, swelling, or anaphylaxis. - Hallucinations or psychosis: altered perception or mental status. - Urinary retention: difficulty emptying the bladder.

Before initiating intrathecal baclofen therapy, several safety considerations are recommended.

- Renal function monitoring: assess kidney status as baclofen is renally excreted. - Blood pressure assessment: watch for hypotension, especially when combined with other depressants. - Seizure risk evaluation: avoid abrupt discontinuation that may precipitate seizures. - Concomitant CNS depressant caution: use with opioids, benzodiazepines, or alcohol only under close supervision. - Depression screening: monitor for mood changes or suicidal thoughts. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake the solution.

Baclofen can interact with other medicines, influencing its safety and effectiveness.

Major Interactions (Avoid): - Opioids or benzodiazepines: combined CNS depression may cause respiratory failure. - Alcohol: additive sedative effect can increase dizziness and hypotension. - Antiepileptic drugs (e.g., phenobarbital): may enhance sedation and impair coordination.

Moderate Interactions (Monitor Closely): - NSAIDs: concurrent use may increase risk of renal impairment. - Antihypertensive agents: may potentiate baclofen‑induced hypotension. - CYP450 inhibitors (e.g., erythromycin): may modestly raise baclofen plasma levels, requiring dose adjustment.