GNH USA

Europe — EMA

Linatil Comp Mite

GNH USA supplies Linatil Comp Mite (Enalapril maleate / Hydrochlorothiazide), an ACE inhibitor and thiazide diuretic for hypertension. Request a quote.

Enalapril Maleate, Hydrochlorothiazide

Request sourcing

1
Pack/s

What is Enalapril Maleate, Hydrochlorothiazide?

Enalapril maleate, the active ingredient in Linatil Comp Mite, is an ACE inhibitor presented as a combination tablet for oral use. It works together with hydrochlorothiazide to treat hypertension in adult patients requiring dual therapy.

GNH USA supplies Linatil Comp Mite as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality, regulatory compliance and reliable logistics across multiple regions, the product meets EU pharmacopoeial standards and is manufactured under strict Good Manufacturing Practices certified.

What is Enalapril Maleate, Hydrochlorothiazide used for?

Linatil Comp Mite, a combination antihypertensive tablet, acts on the renin‑angiotensin system and renal sodium handling to lower blood pressure.

Hypertension: reduces systolic and diastolic pressure in patients with essential hypertension. Edema associated with heart failure: decreases fluid overload and improves symptom control in congestive heart failure. Diabetic nephropathy: slows progression of kidney damage in patients with type 2 diabetes when combined with standard care.

What are the side effects of Enalapril Maleate, Hydrochlorothiazide?

Linatil Comp Mite may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects: - Cough - Dizziness or light‑headedness - Headache - Fatigue - Increased urination - Electrolyte disturbances (e.g., low potassium)

Serious or Rare Side Effects: - Angioedema (swelling of face, lips, tongue) - Severe dehydration or electrolyte imbalance - Hyperkalemia - Acute kidney injury - Significant hypotension - Blood dyscrasias such as agranulocytosis

What precautions apply to Enalapril Maleate, Hydrochlorothiazide?

Before prescribing Linatil Comp Mite, clinicians should consider several safety precautions.

Monitor blood pressure: ensure adequate control and avoid excessive hypotension. Assess renal function: check serum creatinine and eGFR prior to initiation and periodically. Check electrolytes: monitor serum potassium and sodium levels during therapy. Avoid in patients with known angioedema: contraindicated due to risk of recurrence. Use caution in pregnancy: limited data, risk‑benefit assessment required. Store below 25°C: keep in the original container, protect from moisture and light.

What does Enalapril Maleate, Hydrochlorothiazide interact with?

Linatil Comp Mite can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid): - Concomitant use with aliskiren in diabetic patients: increased risk of renal impairment and hyperkalemia. - Potassium‑sparing diuretics or potassium supplements: may cause dangerous hyperkalemia. - NSAIDs (e.g., ibuprofen, naproxen): can reduce antihypertensive effect and impair renal function. - Lithium: ACE inhibition can raise lithium levels, risking toxicity. - Dual therapy with other ACE inhibitors or ARBs: excessive renin‑angiotensin blockade.

Moderate Interactions (Monitor Closely): - Other antihypertensives (beta‑blockers, calcium channel blockers): may enhance blood‑pressure lowering, requiring dose adjustments. - Loop diuretics: additive diuretic effect may lead to volume depletion. - Corticosteroids: can increase sodium retention, counteracting diuretic effect. - Antidiabetic agents: blood‑glucose may improve, requiring monitoring of hypoglycemia. - Antimicrobials such as trimethoprim‑sulfamethoxazole: may increase risk of hyperkalemia.

Frequently asked questions

What is Linatil Comp Mite used for?+
Linatil Comp Mite is a prescription‑only combination tablet that contains enalapril maleate and hydrochlorothiazide. It is primarily used to treat hypertension, helping to lower elevated blood pressure in adult patients who need the combined effect of an ACE inhibitor and a thiazide diuretic.
How does enalapril maleate work?+
Enalapril maleate is an angiotensin‑converting enzyme (ACE) inhibitor. By blocking ACE, it prevents the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This leads to relaxation of blood vessels, reduced aldosterone secretion, and ultimately lower blood pressure.
What is the usual dose of Linatil Comp Mite?+
The appropriate dose of Linatil Comp Mite is determined by the prescribing clinician based on the patient’s blood‑pressure profile, renal function, and response to therapy. Dosage may be adjusted over time, and patients should follow the exact regimen provided by their healthcare professional.
Is Linatil Comp Mite safe during pregnancy or breastfeeding?+
Safety data for Linatil Comp Mite in pregnancy are limited, and the product is generally not recommended unless the potential benefit outweighs the risk. It is also not advised for breastfeeding mothers without medical supervision, as the drug may pass into breast milk and affect the infant.
How do I order Linatil Comp Mite from GNH USA?+
To request Linatil Comp Mite, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Linatil Comp Mite compare with other antihypertensive options?+
Compared with monotherapy ACE inhibitors, the addition of hydrochlorothiazide in Linatil Comp Mite offers a synergistic blood‑pressure‑lowering effect, often allowing better control with a single tablet. Unlike ARBs, ACE inhibitors may cause cough but provide proven benefits in certain cardiovascular conditions. Choice depends on individual patient factors and tolerability.
What are the storage and handling requirements for Linatil Comp Mite?+
Linatil Comp Mite should be stored below 25 °C in its original packaging. Keep the tablets away from moisture, direct sunlight and excessive heat. Do not use the product after the expiry date printed on the label, and keep it out of reach of children.
How is Linatil Comp Mite administered?+
The medication is taken orally, usually once daily, with a full glass of water. It can be taken with or without food, but patients should follow the specific instructions given by their prescriber. Swallow the tablet whole; do not crush or chew unless directed otherwise.
What are the most serious risks associated with Linatil Comp Mite?+
Serious risks include angioedema, which can cause rapid swelling of the face, lips or tongue, and may threaten the airway. Other critical concerns are severe dehydration, hyperkalemia, acute kidney injury, and marked hypotension. Patients should seek immediate medical attention if any of these symptoms develop.
Who should not use Linatil Comp Mite?+
Linatil Comp Mite is contraindicated in patients with a known history of angioedema related to ACE‑inhibitor therapy, severe renal impairment, hyperkalemia, or those who are pregnant without a clear benefit‑risk assessment. It should also be avoided in individuals taking certain prohibited drug combinations, such as aliskiren in diabetic patients.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.

Product details

Drug
Enalapril Maleate, Hydrochlorothiazide
Route
Oral Use
Manufacturer
Hexal A/S
Origin
EU

Related products