Limerik

Piperacillin/tazobactam, the active ingredient in Limerik, is a penicillin β‑lactam antibiotic combination presented as an injectable formulation for intramuscular use. It treats a broad range of serious bacterial infections in hospitalized patients, including those caused by Gram‑negative, Gram‑positive and anaerobic organisms such as Pseudomonas aeruginosa.

GNH USA supplies Limerik as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and oncology centres worldwide. The company adheres to EU GMP standards and provides regulatory documentation for import and distribution globally.

Limerik (piperacillin/tazobactam) is used to treat infections caused by susceptible bacteria across several organ systems. - Complicated intra‑abdominal infections: provides broad coverage including anaerobes and Pseudomonas. - Complicated urinary tract infections: eradicates Gram‑negative pathogens and resistant strains. - Hospital‑acquired pneumonia, including ventilator‑associated pneumonia: achieves bacterial clearance in severe lung infections. - Skin and soft‑tissue infections: treats mixed flora including MRSA‑susceptible strains. - Febrile neutropenia: offers empiric therapy against high‑risk bacterial pathogens.

Adverse reactions to Limerik may vary from mild to severe and should be monitored during therapy.

Common Side Effects: - Diarrhea: loose stools occurring during treatment. - Nausea: feeling of stomach upset. - Injection site pain: local discomfort at the intramuscular site. - Rash: mild skin erythema. - Elevated liver enzymes: transient increase in hepatic transaminases.

Serious or Rare Side Effects: - Anaphylaxis: severe allergic reaction requiring immediate medical attention. - Stevens‑Johnson syndrome: rare mucocutaneous disorder. - Clostridioides difficile‑associated diarrhea: severe colitis risk. - Seizures: especially in patients with renal impairment. - Severe neutropenia: marked reduction in white blood cells. - Acute renal impairment: sudden decline in kidney function.

Before prescribing Limerik, clinicians should consider several precautionary measures to ensure safe use. - Renal function: adjust dose in patients with impaired clearance. - Allergy history: avoid in individuals with known hypersensitivity to penicillins or β‑lactamase inhibitors. - Pregnancy and lactation: use only if benefit outweighs risk, as safety data are limited. - Concurrent antibiotics: evaluate for overlapping toxicity. - Monitoring: observe for signs of hematologic abnormalities such as neutropenia. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Limerik can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid): - Probenecid: reduces renal excretion of piperacillin, increasing toxicity. - Live bacterial vaccines: risk of infection due to antimicrobial activity. - Concurrent use of other β‑lactam antibiotics: may increase risk of hypersensitivity.

Moderate Interactions (Monitor Closely): - Warfarin: possible alteration of INR, monitor coagulation. - Loop diuretics: may increase risk of nephrotoxicity. - Aminoglycosides: monitor renal function due to additive nephrotoxic potential.