Europe — EMA
Lilia (Chlormadinone Acetate, Ethinylestradiol)
GNH USA supplies Lilia (Chlormadinone acetate/ethinylestradiol), a combined oral contraceptive for pregnancy prevention and menstrual regulation.
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What is Chlormadinone Acetate, Ethinylestradiol?
Chlormadinone acetate and ethinylestradiol, the active ingredients in Lilia, are a combined oral contraceptive presented as a tablet for oral use. It prevents pregnancy in women of reproductive age by inhibiting ovulation and creating cervical mucus changes. GNH USA supplies Lilia as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.
What is Chlormadinone Acetate, Ethinylestradiol used for?
Lilia is a combined hormonal contraceptive that acts on the hypothalamic‑pituitary‑ovarian axis to prevent pregnancy. - Pregnancy prevention: provides reliable birth control for women of childbearing potential. - Oral contraception: offers a daily oral regimen to inhibit ovulation and fertilisation. - Menstrual cycle regulation: helps achieve more predictable menstrual bleeding patterns.
What are the side effects of Chlormadinone Acetate, Ethinylestradiol?
Lilia may cause a range of adverse reactions, most of which are mild and transient.
Common Side Effects: - Nausea: mild to moderate stomach upset. - Headache: tension‑type or migraine‑like pain. - Breast tenderness: discomfort or swelling of the breasts. - Irregular bleeding: spotting or breakthrough bleeding between periods.
Serious or Rare Side Effects: - Venous thromboembolism: deep‑vein thrombosis or pulmonary embolism. - Hypertension: new‑onset or worsening high blood pressure. - Severe allergic reaction: rash, swelling, or anaphylaxis.
What precautions apply to Chlormadinone Acetate, Ethinylestradiol?
Before prescribing Lilia, clinicians should evaluate individual risk factors and counsel patients on safety considerations. - Contraindicated in pregnancy: product is classified as pregnancy category X and must not be used. - Avoid in smokers over 35 years: increased risk of cardiovascular events. - Assess history of thromboembolic disorders: risk of clot formation may be elevated. - Monitor blood pressure regularly: may cause or worsen hypertension. - Store at ambient temperature: keep in the original pack, protect from moisture and heat.
What does Chlormadinone Acetate, Ethinylestradiol interact with?
Lilia can interact with several medicines that affect hormone metabolism or increase clotting risk.
Major Interactions (Avoid): - Enzyme‑inducing anticonvulsants (e.g., carbamazepine, phenytoin): may reduce contraceptive efficacy. - Strong CYP3A4 inducers (e.g., rifampicin, griseofulvin): can lower hormone levels. - Other estrogen‑containing products (e.g., hormone replacement therapy): may increase estrogen exposure.
Moderate Interactions (Monitor Closely): - Certain antibiotics (e.g., metronidazole): may slightly diminish effectiveness. - Antifungals such as ketoconazole: can increase hormone concentrations. - St. John’s wort herbal supplement: may decrease contraceptive reliability.



