Ligion

Tadalafil, the active ingredient in Ligion, is a phosphodiesterase type 5 (PDE5) inhibitor presented as an oral tablet for oral use. It treats erectile dysfunction and is also indicated for benign prostatic hyperplasia and pulmonary arterial hypertension in adult males.

GNH USA supplies Ligion as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ligion (tadalafil) is used in conditions related to the nitric‑oxide/cGMP pathway that affect vascular smooth muscle tone.

- Erectile dysfunction: improves the ability to achieve and maintain an erection suitable for sexual activity. - Benign prostatic hyperplasia: reduces lower urinary tract symptoms such as urinary frequency and urgency. - Pulmonary arterial hypertension: enhances exercise capacity by lowering pulmonary vascular resistance.

Adverse reactions may occur with tadalafil therapy.

Common Side Effects: - Headache - Flushing - Dyspepsia - Nasal congestion

Serious or Rare Side Effects: - Sudden vision loss (non‑arteritic anterior ischemic optic neuropathy) - Priapism lasting longer than four hours - Severe hypotension or syncope

Before using Ligion, consider the following safety measures.

- Cardiovascular assessment: evaluate for recent myocardial infarction or unstable angina. - Concomitant nitrate therapy: avoid due to risk of profound hypotension. - Severe hepatic or renal impairment: dose adjustment may be required. - Visual or auditory disturbances: discontinue and seek medical attention if they occur. - Allergic reactions: stop the drug if signs of hypersensitivity develop. - Store at room temperature: keep in the original container, protect from moisture and heat.

Tadalafil can interact with several medication classes.

Major Interactions (Avoid): - Nitrates (e.g., nitroglycerin): risk of severe hypotension. - Guanylate cyclase stimulators (e.g., riociguat): additive vasodilatory effect. - Potent CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase tadalafil exposure.

Moderate Interactions (Monitor Closely): - Antihypertensive agents: possible additive blood pressure lowering. - CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce efficacy of tadalafil.