Lidocaine Prilocaine Zentiva

Lidocaine and Prilocaine, the active ingredients in Lidocaine Prilocaine Zentiva, are local anesthetics presented as a topical formulation for cutaneous use. They provide rapid, reversible surface anesthesia for minor skin and mucous membrane procedures, helping to reduce pain and discomfort during dermatological interventions.

GNH USA supplies Lidocaine Prilocaine Zentiva as a licensed, GDP‑compliant international pharmaceutical product, serving hospitals, pharmacies and clinics worldwide with reliable sourcing and regulatory support. The product complies with EU quality standards and is manufactured under strict GMP conditions.

Lidocaine Prilocaine Zentiva is a topical anesthetic used to numb skin and mucous membranes for minor procedures.

- Local anesthesia of skin and mucous membranes: provides temporary loss of sensation for minor surgical or diagnostic interventions. - Pain relief for minor dermatological procedures: reduces discomfort during biopsies, laser therapy, or excisions. - Pre‑procedural analgesia for superficial needle insertions: numbs the area before injections or blood draws.

Adverse reactions may occur following topical application of lidocaine/prilocaine combinations.

Common Side Effects: - Mild burning or stinging sensation at the application site - Transient erythema or redness - Localized itching or pruritus - Tingling or paresthesia - Mild swelling of the applied area

Serious or Rare Side Effects: - Allergic contact dermatitis with rash or edema - Systemic toxicity (e.g., CNS symptoms such as dizziness, seizures) if excessive area is treated - Methemoglobinemia, a rare blood disorder associated with prilocaine - Severe cardiac arrhythmias in cases of systemic absorption - Anaphylactic reaction requiring emergency care

Before using Lidocaine Prilocaine Zentiva, consider the following safety measures.

- Assess for allergy: avoid use in patients with known hypersensitivity to amide‑type local anesthetics. - Limit application area: do not exceed the recommended surface area to prevent systemic absorption. - Avoid use on broken skin: apply only to intact epidermis or mucosa. - Use with caution in patients with cardiovascular or hepatic impairment. - Pregnancy and lactation: consult the prescriber as safety data are limited. - Store at room temperature: keep in the original container, protect from moisture and light.

Lidocaine Prilocaine Zentiva may interact with other medicines; awareness of potential interactions helps maintain safety.

Major Interactions (Avoid): - Concurrent use with other potent local anesthetics: may increase risk of systemic toxicity. - Co‑administration with monoamine oxidase inhibitors (MAOIs): may potentiate central nervous system effects.

Moderate Interactions (Monitor Closely): - Use with CYP450 inhibitors (e.g., cimetidine) may slow lidocaine metabolism. - Concomitant use of drugs affecting cardiac conduction (e.g., class I antiarrhythmics) may enhance cardiac effects. - Combination with methemoglobin‑inducing agents (e.g., dapsone) may raise the risk of methemoglobinemia.