Lidocaine/Prilocaine Aguettant

Lidocaine, the active ingredient in Lidocaine/Prilocaine Aguettant, is a local anesthetic presented as a topical formulation for cutaneous use. It provides surface anesthesia for minor skin procedures, mucosal surfaces and superficial wounds.

GNH USA supplies Lidocaine/Prilocaine Aguettant as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Lidocaine/Prilocaine is a local anesthetic used on the skin and mucous membranes to achieve temporary loss of sensation. - Minor skin procedures: provides rapid surface anesthesia for biopsies, suturing or laser treatment. - Mucous membrane anesthesia: numbs oral, nasal or genital mucosa during diagnostic or therapeutic procedures. - Superficial wound or burn pain relief: reduces pain and discomfort from shallow injuries or first‑degree burns.

Adverse reactions are generally limited to the application site, but systemic absorption can produce rare serious events.

Common Side Effects: - Mild skin irritation or erythema - Itching or burning sensation at the site - Localized edema or swelling - Allergic contact dermatitis - Transient numbness lasting longer than expected - Dryness or peeling of the treated skin

Serious or Rare Side Effects: - Systemic toxicity (e.g., dizziness, seizures, CNS depression) - Methemoglobinemia leading to cyanosis - Severe allergic reaction or anaphylaxis - Cardiac arrhythmias or conduction disturbances - Persistent numbness or paresthesia - Tissue necrosis with prolonged occlusive use

Before applying Lidocaine/Prilocaine, consider patient history and proper usage to minimise risk. - Allergy assessment: confirm no known hypersensitivity to amide‑type local anesthetics. - Application area: avoid use on broken, infected or inflamed skin unless directed. - Surface area limit: restrict total treated area to the amount recommended by the prescriber. - Patient monitoring: observe for signs of systemic toxicity, especially in children or the elderly. - Special populations: use with caution in infants, pregnant or lactating women when benefits outweigh risks. - Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Lidocaine/Prilocaine may interact with other agents that affect sodium channels or metabolic pathways.

Major Interactions (Avoid): - Concurrent use of other amide‑type local anesthetics (risk of cumulative toxicity). - Class I antiarrhythmic drugs such as quinidine or procainamide (enhanced cardiac effects). - High‑dose epinephrine formulations (increased systemic absorption).

Moderate Interactions (Monitor Closely): - Strong CYP3A4 inhibitors (e.g., erythromycin, ketoconazole) that may raise plasma levels. - Methemoglobin‑inducing agents such as dapsone or nitrites (additive risk of methemoglobinemia). - Other medications that lower seizure threshold (e.g., tramadol, bupropion).