Lidocaïne/Prilocaïne Zentiva

Lidocaine, the active ingredient in Lidocaïne/Prilocaïne Zentiva, is a local anesthetic presented as a topical formulation for skin and mucosal use. It provides surface numbness to facilitate minor surgical, diagnostic or cosmetic procedures by temporarily blocking nerve signal transmission.

GNH USA supplies Lidocaïne/Prilocaïne Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Lidocaïne/Prilocaïne Zentiva is a topical anesthetic used to numb superficial tissues in various minor procedures.

- Minor skin surgery: provides rapid surface anesthesia to reduce procedural pain. - Dermatologic procedures (e.g., laser therapy, microdermabrasion): minimizes discomfort during treatment. - Mucosal anesthesia (e.g., oral, genital examinations): numbs the area to facilitate examination or minor interventions.

Topical application of lidocaine/prilocaine may be associated with local and systemic adverse reactions.

Common Side Effects: - Burning or stinging sensation at the application site. - Redness or mild erythema. - Itching or mild rash. - Swelling or edema of the treated area. - Dizziness or light‑headedness. - Transient numbness extending beyond the intended zone.

Serious or Rare Side Effects: - Methemoglobinemia, presenting with cyanosis and shortness of breath. - Severe allergic reactions, including anaphylaxis. - Systemic toxicity such as seizures, cardiac arrhythmias, or hypotension. - Skin necrosis or ulceration at the site of prolonged exposure. - Secondary infection of the treated area.

When using Lidocaïne/Prilocaïne Zentiva, consider the following safety measures.

- Assess for hypersensitivity: avoid if the patient has known allergy to amide local anesthetics. - Apply to intact skin only: do not use on broken, inflamed, or infected skin. - Limit application area: adhere to recommended surface‑area limits to reduce systemic absorption. - Avoid concurrent use with other topical anesthetics: risk of cumulative toxicity. - Monitor patients with cardiovascular disease: systemic absorption may affect heart rhythm. - Store at room temperature: keep in the original pack, protect from moisture and light.

Lidocaïne/Prilocaïne Zentiva can interact with other substances that affect its safety profile.

Major Interactions (Avoid): - Concurrent use with other amide local anesthetics: increased risk of systemic toxicity. - Co‑administration with methemoglobin‑inducing agents (e.g., benzocaine, dapsone): heightened risk of methemoglobinemia.

Moderate Interactions (Monitor Closely): - Use with vasoconstrictors such as epinephrine: may alter absorption rate and duration of effect. - Combination with anticoagulants or antiplatelet drugs: potential for increased bleeding if invasive procedures are performed. - Interaction with CYP2D6 inhibitors (e.g., fluoxetine, quinidine): may modestly affect metabolism of prilocaine.