Lidocaïne/Prilocaïne Bio Valys

Lidocaine and Prilocaine, the active ingredients in Lidocaïne/Prilocaïne Bio Valys, are local anesthetics presented as a topical formulation for transdermal use. They provide reversible inhibition of nerve impulse transmission, delivering surface numbness for minor skin procedures and relief of superficial tissue pain.

GNH USA supplies Lidocaïne/Prilocaïne Bio Valys as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Lidocaine/Prilocaine is a local anesthetic used to achieve surface numbness in various minor dermatologic and surgical procedures.

Minor skin surgery: provides anesthesia of the epidermis and dermis to facilitate incision and suturing. Dermatologic laser or cryotherapy: reduces procedural pain and improves patient comfort. Superficial wound debridement: offers temporary pain relief during cleaning of minor wounds.

Application of lidocaine/prilocaine may be associated with local and systemic adverse reactions.

Common Side Effects: - Transient erythema at the application site - Mild burning or stinging sensation - Pruritus or itching

Serious or Rare Side Effects: - Allergic contact dermatitis with rash and edema - Systemic toxicity (e.g., dizziness, seizures, cardiovascular effects) - Methemoglobinemia, a rare blood disorder associated with prilocaine

When using lidocaine/prilocaine, several precautions should be observed to minimise risk. - Allergy assessment: avoid use in patients with known hypersensitivity to amide‑type local anesthetics. - Application area: limit to intact, non‑mucosal skin; do not cover large surface areas. - Dose limitation: follow prescriber instructions to prevent excessive systemic absorption. - Concomitant anesthetics: monitor total dose when used with other local anesthetics. - Patient factors: use with caution in individuals with cardiac, hepatic or renal impairment. - Store at below 25°C: keep in the original packaging, protect from moisture and light.

Lidocaine/prilocaine may interact with other medicines; awareness of the most relevant interactions is important.

Major Interactions (Avoid): - Class I antiarrhythmic agents (e.g., quinidine, procainamide): increased risk of cardiotoxicity. - Strong CYP2C9 inhibitors (e.g., fluconazole): may raise plasma levels of prilocaine.

Moderate Interactions (Monitor Closely): - Additional local anesthetics: cumulative dose may exceed safe limits. - Beta‑blockers: potential enhancement of central nervous system effects. - Monoamine oxidase inhibitors: possible additive CNS depression.