Licolos Plus

Losartan potassium, the active ingredient in Licolos Plus, is an angiotensin II receptor blocker presented as an oral tablet for systemic use. It is combined with hydrochlorothiazide, a thiazide diuretic, to treat hypertension in adult patients.

GNH USA supplies Licolos Plus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Licolos Plus is an antihypertensive combination that lowers blood pressure by targeting the renin‑angiotensin system and promoting diuresis. - Hypertension: provides effective reduction of systolic and diastolic blood pressure. - Hypertension with volume overload: adds diuretic action to improve control in patients retaining fluid. - Hypertension in diabetic patients: helps protect renal function while managing blood pressure.

Adverse reactions may occur with any antihypertensive therapy.

Common Side Effects: - Dizziness or light‑headedness, especially after the first dose. - Headache. - Fatigue or weakness. - Increased urination. - Electrolyte disturbances such as low potassium. - Mild gastrointestinal upset.

Serious or Rare Side Effects: - Severe hypotension. - Acute kidney injury. - Hyperkalemia. - Allergic reactions including rash or angioedema. - Liver enzyme elevations. - Blood dyscrasias such as agranulocytosis.

Before initiating therapy, consider patient‑specific factors and monitor appropriately. - Pregnancy: avoid use; classified as Category D due to fetal risk. - Renal impairment: assess kidney function and adjust dose if needed. - Hepatic disease: use with caution; monitor liver enzymes. - Electrolyte balance: check serum potassium and sodium regularly. - Concomitant potassium‑sparing agents: increase risk of hyperkalemia. - Store at ambient temperature: keep below 25°C, in the original container, protected from moisture and light.

Drug interactions can modify the efficacy or safety of the combination.

Major Interactions (Avoid): - Aliskiren in patients with diabetes or renal impairment: risk of severe hypotension and renal dysfunction. - Potassium supplements or potassium‑sparing diuretics: may cause dangerous hyperkalemia. - NSAIDs (e.g., ibuprofen, naproxen): can blunt antihypertensive effect and worsen renal function.

Moderate Interactions (Monitor Closely): - Lithium: increased lithium levels, monitor for toxicity. - Antidiabetic agents: may require dose adjustment due to enhanced glucose lowering. - Other antihypertensives (e.g., ACE inhibitors, beta‑blockers): monitor blood pressure for additive effects. - CYP2C9 inhibitors (e.g., fluconazole): may raise losartan levels. - Thiazide‑sparing diuretics: monitor electrolytes for imbalance.