Levosert

Levonorgestrel, the active ingredient in Levosert, is a progestogen presented as a 52 mg intrauterine system for intrauterine use. It provides long‑acting reversible contraception by preventing ovulation and implantation in women of reproductive age.

GNH USA supplies Levosert as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance across markets. The company leverages a robust supply chain and quality assurance processes to meet the needs of global healthcare providers.

Levosert (levonorgestrel) is a hormonal contraceptive that acts within the reproductive system to prevent pregnancy.

Contraception (long‑acting reversible contraceptive): Provides continuous birth control for up to five years after insertion of the intrauterine system.

Levosert may be associated with a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects: - Irregular bleeding or spotting: Unpredictable menstrual bleeding patterns, especially during the first six months. - Cramps or pelvic pain: Mild to moderate discomfort in the lower abdomen. - Headache: Transient headache episodes. - Breast tenderness: Mild soreness or swelling of the breasts. - Acne or skin changes: Occasional worsening of acne.

Serious or Rare Side Effects: - Uterine perforation: Rare injury to the uterine wall during insertion. - Expulsion of the device: The IUS may be partially or completely expelled. - Pelvic inflammatory disease: Infection that can affect reproductive organs. - Allergic reaction: Severe hypersensitivity to levonorgestrel or device components.

Before using Levosert, certain precautions and warnings should be considered to ensure safe and effective use. - Pregnancy status: Do not insert in women who are already pregnant; confirm negative pregnancy test prior to placement. - Breastfeeding: Use with caution; discuss benefits and risks with healthcare provider. - Uterine abnormalities: Evaluate for fibroids, septum, or scarring that may increase insertion complications. - Infection risk: Treat any active pelvic infection before insertion. - Copper IUD use: Not applicable; avoid concurrent use of other intrauterine devices. - Store at room temperature: Keep in original packaging, protect from moisture and direct sunlight.

Levosert can interact with other medicines or substances that affect hormone metabolism or uterine environment.

Major Interactions (Avoid): - Enzyme inducers (e.g., rifampin, carbamazepine, phenytoin): May reduce levonorgestrel levels, decreasing contraceptive efficacy. - Antifungal agents (e.g., griseofulvin): Can lower hormone concentrations, risking failure.

Moderate Interactions (Monitor Closely): - Antibiotics (e.g., tetracycline, metronidazole): May have a modest effect on hormone levels; monitor for breakthrough bleeding. - Antiretroviral drugs (e.g., efavirenz): May slightly reduce efficacy; consider additional contraception. - Herbal supplements (e.g., St. John’s wort): Potential enzyme induction; advise caution.