Levonorgestrel Stada

Levonorgestrel, the active ingredient in Levonorgestrel Stada, is a progestin presented as an oral formulation for oral use. It is used for hormonal contraception, including emergency contraception, in women of reproductive age.

GNH USA supplies Levonorgestrel Stada as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Levonorgestrel is a progestin used in hormonal contraception to prevent pregnancy.

- Emergency contraception: provides post‑coital prevention of pregnancy when taken within the recommended time window. - Regular contraception: used in progestin‑only regimens to inhibit ovulation and thicken cervical mucus. - Menstrual cycle regulation: may be employed off‑label to manage irregular bleeding patterns.

Levonorgestrel is generally well tolerated, but a range of adverse reactions have been reported.

Common Side Effects: - Nausea - Headache - Breast tenderness - Irregular vaginal bleeding - Mood changes - Abdominal pain

Serious or Rare Side Effects: - Thromboembolic events (deep‑vein thrombosis, pulmonary embolism) - Severe allergic reaction (anaphylaxis) - Liver dysfunction or jaundice - Persistent high blood pressure - Ovarian cyst rupture (rare)

Before initiating Levonorgestrel therapy, several safety considerations should be reviewed.

- Medical history review: assess for thromboembolic risk, liver disease, or hormone‑sensitive cancers. - Concurrent medication check: avoid use with enzyme‑inducing drugs that may reduce efficacy. - Pregnancy status: confirm the patient is not pregnant before starting. - Breastfeeding: evaluate benefits versus potential effects on the infant. - Smoking: advise cessation, especially in women over 35 years of age. - Store at ambient temperature: keep below 25°C, retain in the original packaging, and protect from moisture.

Levonorgestrel may interact with other medicines, altering its effectiveness or safety profile.

Major Interactions (Avoid): - Enzyme inducers (e.g., rifampicin, carbamazepine): may markedly reduce contraceptive effectiveness. - Antifungal azoles (e.g., ketoconazole): can increase hormone levels, raising risk of side effects. - Protease inhibitor antiretrovirals: may alter hormone metabolism and affect efficacy.

Moderate Interactions (Monitor Closely): - Anticonvulsants (e.g., phenytoin): may modestly decrease contraceptive efficacy. - St. John’s wort: may reduce plasma concentrations of levonorgestrel. - Certain antibiotics (e.g., tetracycline): limited effect but monitor for breakthrough bleeding.