Levonorgestrel

Levonorgestrel, the active ingredient in Levonorgestrel, is a progestogen presented as a tablet for oral use. It is employed to prevent pregnancy, either as emergency contraception or as a progestin‑only contraceptive, and is also used in hormone therapy.

GNH USA supplies Levonorgestrel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality, regulatory compliance, and reliable delivery.

Levonorgestrel is a progestogen used in several contraceptive and hormonal indications.

- Emergency contraception: Provides a high‑dose regimen to prevent pregnancy after unprotected intercourse. - Progestin‑only contraception: Maintains contraceptive efficacy when taken daily as a single‑dose pill. - Hormone therapy: Supplies progestogenic activity for certain hormone replacement regimens.

Levonorgestrel may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Headache: tension‑type or migraine‑like pain. - Breast tenderness: discomfort or swelling of the breasts. - Irregular bleeding: spotting or changes in menstrual flow. - Mood changes: irritability or emotional fluctuations. - Abdominal pain: cramping or discomfort.

Serious or Rare Side Effects: - Thromboembolic events: deep‑vein thrombosis or pulmonary embolism. - Severe allergic reaction: anaphylaxis, hives, or swelling of the face. - Liver dysfunction: jaundice or elevated liver enzymes. - Pregnancy complications: if taken during early pregnancy, may affect fetal development.

Before prescribing Levonorgestrel, clinicians should consider several safety aspects.

- Medical review: assess for active thromboembolic disease, severe liver impairment, or known hypersensitivity. - Pregnancy status: avoid use in confirmed pregnancy unless benefits outweigh risks. - Breastfeeding: evaluate risk‑benefit, as drug may pass into milk. - Concomitant medications: review drugs that may reduce efficacy, such as enzyme inducers. - Patient counseling: advise on possible menstrual changes and when to seek medical help. - Store at ambient temperature: keep below 25°C, retain in original packaging, protect from moisture and direct sunlight.

Levonorgestrel can interact with other medicines, altering its effectiveness or safety profile.

Major Interactions (Avoid): - Antiepileptic enzyme inducers (e.g., carbamazepine, phenytoin): may markedly reduce contraceptive efficacy. - Rifampicin: decreases plasma concentrations, compromising pregnancy prevention. - St. John’s wort: herbal inducer that can lower drug levels.

Moderate Interactions (Monitor Closely): - Antifungal azoles (e.g., ketoconazole): may increase levonorgestrel exposure, raising side‑effect risk. - Protease inhibitor antiretrovirals: can alter metabolism, requiring clinical monitoring. - Estrogen‑containing hormonal therapies: may affect bleeding patterns and overall hormonal balance.