Levonorgestrel

Levonorgestrel, the active ingredient in Levonorgestrel, is a progestogen (progestin) presented as an oral tablet for oral use. It is employed to prevent pregnancy, including emergency contraception, and is available without a prescription in many EU markets.

GNH USA supplies Levonorgestrel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to EU quality standards and providing reliable global distribution while ensuring batch consistency, regulatory compliance and timely delivery to meet the needs of healthcare providers.

Levonorgestrel is a synthetic progestogen used within the hormonal contraceptive pathway to prevent unintended pregnancy. - Emergency contraception: prevents pregnancy after unprotected intercourse when taken within the recommended time frame. - Regular contraception: used as part of combined oral contraceptive regimens to inhibit ovulation and maintain contraceptive efficacy. - Prevention of pregnancy: provides a hormonal method to reduce the risk of conception when used according to approved guidelines.

Levonorgestrel may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Headache: occasional tension‑type headache. - Breast tenderness: temporary discomfort in breast tissue. - Irregular bleeding: spotting or changes in menstrual flow. - Fatigue: feeling unusually tired. - Abdominal pain: mild cramping.

Serious or Rare Side Effects: - Thromboembolic events: rare clot formation in veins or arteries. - Severe allergic reaction: hives, swelling, or anaphylaxis. - Liver dysfunction: abnormal liver enzymes or jaundice. - Pregnancy complications: if taken during early pregnancy, may affect fetal development.

Before using Levonorgestrel, consider the following safety measures. - Pregnancy testing: confirm non‑pregnant status prior to initiation. - Breastfeeding: consult a healthcare professional as safety data are limited. - Drug interactions: review concomitant medications that may reduce efficacy. - Medical conditions: assess for history of thromboembolic disease or hormone‑sensitive cancers. - Store at ambient temperature: keep below 25 °C, retain original packaging, protect from moisture and light.

Levonorgestrel can interact with several medicines that alter its effectiveness.

Major Interactions (Avoid): - Enzyme‑inducing antiepileptics (e.g., carbamazepine, phenytoin, rifampicin): may markedly reduce contraceptive efficacy. - Certain antiretroviral protease inhibitors: can increase levonorgestrel levels and risk of side effects.

Moderate Interactions (Monitor Closely): - Antifungal azoles (e.g., ketoconazole): may raise plasma concentrations. - St. John’s wort: may lower effectiveness. - Antibiotics such as rifampin: monitor for reduced contraceptive protection.