Europe — EMA
Levonance 20 (Ethinylestradiol, Levonorgestrel)
GNH USA supplies Levonance 20 (Ethinylestradiol / Levonorgestrel), a combined oral contraceptive for prevention of pregnancy.
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What is Ethinylestradiol, Levonorgestrel?
Ethinylestradiol / Levonorgestrel, the active ingredients in Levonance 20, are a combined oral contraceptive presented as a 20 µg/100 µg tablet for oral use. They work to prevent pregnancy in women of reproductive age by inhibiting ovulation and altering cervical mucus and the endometrium.
GNH USA supplies Levonance 20 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable access to this EU‑approved hormonal contraceptive.
What is Ethinylestradiol, Levonorgestrel used for?
Levonance 20, a combined oral contraceptive, is used to prevent pregnancy by acting on the hormonal regulation of the menstrual cycle.
Contraception: provides reliable prevention of unintended pregnancy when taken as directed. Family planning: supports planned childbearing by offering reversible oral birth control. Hormonal contraception: offers a low‑dose estrogen‑progestin regimen for women seeking oral birth control.
What are the side effects of Ethinylestradiol, Levonorgestrel?
Levonance 20 may cause a range of adverse reactions. Most are mild and transient.
Common Side Effects: - Nausea: mild stomach upset, especially during the first cycles. - Headache: tension‑type or migraine‑like pain. - Breast tenderness: temporary swelling or discomfort. - Spotting between periods: light vaginal bleeding.
Serious or Rare Side Effects: - Deep vein thrombosis: blood clot formation in the legs. - Pulmonary embolism: clot migration to the lungs. - Stroke or myocardial infarction: rare cardiovascular events. - Severe allergic reaction: rash, swelling, or anaphylaxis. - Liver tumor: very rare hepatic adenoma. - Hyperbilirubinemia: unusual jaundice.
What precautions apply to Ethinylestradiol, Levonorgestrel?
Before prescribing Levonance 20, clinicians should evaluate individual risk factors and counsel patients on safe use.
Contraindicated in pregnancy: product is category X and must not be used by pregnant women. Avoid in smokers over 35: increased risk of cardiovascular events. Screen for thromboembolic risk: assess history of clotting disorders. Monitor blood pressure: may cause slight elevation. Store at ambient temperature: keep below 25°C in the original pack, protect from moisture.
What does Ethinylestradiol, Levonorgestrel interact with?
Levonance 20 can interact with other medicines, affecting its efficacy or safety.
Major Interactions (Avoid): - Enzyme‑inducing anticonvulsants (e.g., carbamazepine): reduce hormone levels. - Rifampin: may markedly decrease contraceptive effectiveness. - Protease inhibitors (e.g., ritonavir): can increase hormone concentrations. - St. John’s wort: herbal inducer that lowers efficacy.
Moderate Interactions (Monitor Closely): - Tetracycline antibiotics: may slightly reduce contraceptive effect. - Fluconazole and other azole antifungals: can increase hormone levels. - Diuretics: may affect fluid balance and blood pressure.



