Levofolic

Levoleucovorin Disodium, the active ingredient in Levofolic, is a folate analog presented as a sterile injectable solution for intravenous use. It replenishes reduced folate pools in cells and is employed to mitigate the toxic effects of antifolate chemotherapy agents and to support certain cancer treatment regimens.

GNH USA supplies Levofolic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide. The company adheres to strict quality standards and provides reliable global distribution.

Levofolic (levoleucovorin disodium) is used in oncology and supportive care to modulate folate pathways and protect normal cells during chemotherapy. - Methotrexate toxicity: rescues normal cells from high‑dose methotrexate–induced damage. - 5‑Fluorouracil‑based regimens: enhances antitumor activity by stabilizing the drug‑target complex. - Folate deficiency: restores intracellular folate levels when oral supplementation is insufficient.

Levofolic may be associated with a range of adverse reactions, most of which are mild and reversible.

Common Side Effects: - Nausea: mild to moderate gastrointestinal upset. - Headache: transient cranial discomfort. - Rash: erythematous skin eruption. - Fever: low‑grade temperature elevation.

Serious or Rare Side Effects: - Anaphylaxis: severe allergic reaction with airway compromise. - Acute renal failure: sudden loss of kidney function. - Hepatic dysfunction: elevated transaminases or jaundice.

When using Levofolic, clinicians should observe several precautionary measures to ensure patient safety. - Renal function: assess baseline creatinine and monitor during therapy. - Hepatic function: evaluate liver enzymes before and during treatment. - Pregnancy: avoid unless benefits outweigh potential risks, as data are limited. - Concomitant antifolate chemotherapy: coordinate timing to prevent antagonism. - Hypersensitivity: discontinue immediately if signs of allergic reaction appear. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Levofolic can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid): - High‑dose methotrexate: concurrent administration without proper rescue may increase toxicity. - 5‑Fluorouracil: simultaneous use can amplify cytotoxic effects, requiring dose adjustment.

Moderate Interactions (Monitor Closely): - Nephrotoxic agents (e.g., aminoglycosides): monitor renal parameters. - Hepatotoxic drugs (e.g., isoniazid): watch liver function tests. - Anticonvulsants affecting folate (e.g., phenytoin): assess folate status. - Vitamin B12 deficiency: may reduce effectiveness, consider supplementation.