Levofolene

Levoleucovorin, the active ingredient in Levofolene, is a folinic acid (reduced folate) presented as an oral formulation for systemic use. It serves as an antidote and rescue agent that mitigates toxicity from antifolate chemotherapy such as methotrexate and 5‑fluorouracil, and it also helps correct folate deficiency in patients undergoing cancer treatment, particularly in adult and pediatric oncology protocols.

GNH USA supplies Levofolene as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide, and clinical research institutions through reliable logistics.

Levofolene (levoleucovorin) is used in clinical settings to rescue patients from antifolate‑induced toxicity and to support folate metabolism.

- High‑dose methotrexate rescue: restores folate pools and reduces methotrexate‑related toxicity. - 5‑fluorouracil adjunct therapy: enhances tolerability of 5‑FU‑based regimens by supplying reduced folate. - Folate deficiency prevention: corrects folate deficiency in patients receiving folate‑depleting chemotherapy.

Levofolene is generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Nausea: mild to moderate upset stomach. - Vomiting: occasional episodes after dosing. - Diarrhea: transient loose stools. - Rash: mild skin erythema. - Headache: occasional dull headache. - Fatigue: feeling of tiredness.

Serious or Rare Side Effects: - Anaphylaxis: severe allergic reaction requiring immediate medical attention. - Neutropenia: marked reduction in white blood cells. - Thrombocytopenia: low platelet count leading to bleeding risk. - Renal dysfunction: impaired kidney function. - Hepatic toxicity: elevated liver enzymes. - Severe skin reactions: such as Stevens‑Johnson syndrome.

Levofolene should be used with appropriate clinical monitoring. - Renal function: assess baseline and monitor during therapy. - Hepatic function: evaluate liver enzymes before and during treatment. - Concurrent chemotherapy: coordinate timing to avoid antagonism. - Pregnancy: use only if clearly needed after risk‑benefit assessment. - Pediatric patients: dose may require adjustment based on weight and age. - Store at ambient temperature: keep in the original pack, protect from moisture and light.

Levofolene may interact with other medicines; monitoring is advised.

Major Interactions (Avoid): - High‑dose folic acid supplements: may diminish intended rescue effect. - Cytarabine: concurrent use can increase toxicity.

Moderate Interactions (Monitor Closely): - NSAIDs: may affect renal clearance of levoleucovorin. - Penicillins: can increase renal excretion, altering levels. - Proton pump inhibitors: may alter gastrointestinal absorption. - Sulfonamides: potential additive effect on folate pathways.