Levofloxacino Accord

Levofloxacin, the active ingredient in Levofloxacino Accord, is a fluoroquinolone antibiotic presented as an oral tablet for oral use. It treats a range of bacterial infections, including respiratory, urinary, and skin infections, in adult patients. The drug works by inhibiting bacterial DNA replication, making it effective against susceptible Gram‑negative and Gram‑positive organisms.

GNH USA supplies Levofloxacino Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to meet global demand.

Levofloxacin is indicated for several bacterial infections affecting the respiratory, urinary and skin systems.

- Community‑acquired respiratory tract infections: resolves infection and improves respiratory symptoms. - Acute bacterial sinusitis: eradicates the causative pathogens and relieves sinus congestion. - Acute exacerbations of chronic bronchitis: reduces bacterial load and shortens the duration of exacerbation. - Uncomplicated urinary tract infections: clears the infection and prevents recurrence. - Skin and soft‑tissue infections: eliminates the infecting bacteria and promotes wound healing.

Levofloxacin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea - Diarrhea - Headache - Dizziness

Serious or Rare Side Effects: - Tendon rupture or inflammation - QT interval prolongation - Severe allergic reactions such as Stevens‑Johnson syndrome

Levofloxacin requires careful patient assessment and monitoring.

- Renal impairment: adjust therapy based on renal function and monitor creatinine. - History of tendon disorders: avoid use and discontinue if tendon pain occurs. - Concomitant QT‑prolonging drugs: monitor cardiac rhythm and avoid combined use. - Pregnancy and lactation: use only if clearly needed after risk‑benefit assessment. - Pediatric use: not recommended unless benefits outweigh risks. - Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

Levofloxacin can interact with several medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid): - Antacids containing aluminum or magnesium: reduce levofloxacin absorption; separate administration by at least 2 hours. - Non‑steroidal anti‑inflammatory drugs (NSAIDs): increase risk of central nervous system stimulation and seizures. - Warfarin: may enhance anticoagulant effect; monitor INR closely.

Moderate Interactions (Monitor Closely): - Theophylline: levofloxacin can raise plasma theophylline levels; monitor for toxicity. - Cyclosporine: may increase cyclosporine concentrations; adjust dose as needed. - Diabetic agents (e.g., insulin, sulfonylureas): may cause hypoglycemia; monitor blood glucose.