GNH USA

Europe — EMA

Levofloxacine Zentiva (Levofloxacin Hemihydrate)

GNH USA supplies Levofloxacine Zentiva (Levofloxacin), a fluoroquinolone antibiotic for urinary, respiratory and skin infections.

Levofloxacin Hemihydrate

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What is Levofloxacin Hemihydrate?

Levofloxacin, the active ingredient in Levofloxacine Zentiva, is a fluoroquinolone antibiotic presented as an oral dosage form for oral use. It treats a range of bacterial infections in adults and children when prescribed by a qualified health professional.

GNH USA supplies Levofloxacine Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Levofloxacin Hemihydrate used for?

Levofloxacine Zentiva is a broad‑spectrum fluoroquinolone used to manage bacterial infections in various organ systems. - Urinary tract infections: effective treatment of acute uncomplicated and complicated infections. - Respiratory tract infections: clears community‑acquired pneumonia and acute exacerbations of chronic bronchitis. - Skin and soft tissue infections: resolves cellulitis, wound infections, and abscesses. - Prostatitis: eradicates bacterial prostatitis resistant to other agents. - Complicated intra‑abdominal infections: provides coverage for mixed aerobic and anaerobic pathogens.

What are the side effects of Levofloxacin Hemihydrate?

Levofloxacine Zentiva may cause a variety of adverse reactions, ranging from mild to serious.

Common Side Effects: - Nausea: mild to moderate upset stomach. - Diarrhea: loose stools, sometimes watery. - Headache: transient cranial discomfort. - Dizziness: sensation of light‑headedness.

Serious or Rare Side Effects: - Tendon rupture: especially Achilles tendon, may occur without warning. - QT prolongation: can lead to cardiac arrhythmias. - Severe allergic reaction: includes rash, swelling, and anaphylaxis. - Clostridioides difficile infection: severe colitis following disruption of gut flora.

What precautions apply to Levofloxacin Hemihydrate?

Before prescribing Levofloxacine Zentiva, clinicians should consider several safety factors. - Renal function: assess and adjust in severe impairment. - History of tendon disorders: avoid use in patients with prior tendon injury. - Cardiac risk: monitor QT interval in patients with known prolongation. - Concomitant NSAIDs: increased risk of tendon toxicity. - Pregnancy and lactation: use only if clearly needed, as safety is not established. - Store at below 25°C: keep in the original pack, protect from moisture.

What does Levofloxacin Hemihydrate interact with?

Levofloxacine Zentiva can interact with other medicines, requiring careful management.

Major Interactions (Avoid): - Antacids containing aluminum or magnesium: reduce levofloxacin absorption. - Warfarin: may potentiate anticoagulant effect and increase bleeding risk. - Glucocorticoids: increase risk of tendon rupture.

Moderate Interactions (Monitor Closely): - NSAIDs: may increase risk of central nervous system stimulation. - Theophylline: levofloxacin can raise theophylline plasma concentration, risking toxicity.

Frequently asked questions

What infections is Levofloxacine Zentiva used for?+
Levofloxacine Zentiva is indicated for a range of bacterial infections, including urinary tract infections, respiratory tract infections such as pneumonia, skin and soft‑tissue infections, prostatitis, and complicated intra‑abdominal infections. It is prescribed when a fluoroquinolone is appropriate for the identified or suspected pathogen.
How does levofloxacin work to treat bacterial infections?+
Levofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes that unwind and reseal DNA during replication and transcription. By preventing these processes, the drug halts bacterial growth and leads to cell death, providing a bactericidal effect against many Gram‑positive and Gram‑negative organisms.
What is the usual dose of Levofloxacine Zentiva?+
The exact dosage of Levofloxacine Zentiva is determined by the prescribing clinician based on the infection type, severity, patient age, renal function, and other clinical factors. Only a qualified health professional can set the appropriate regimen.
Is Levofloxacine Zentiva safe during pregnancy or breastfeeding?+
Safety data for levofloxacin in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a healthcare provider.
How do I order Levofloxacine Zentiva from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.
How does Levofloxacine Zentiva compare with other fluoroquinolones?+
Levofloxacine Zentiva contains levofloxacin, the L‑isomer of ofloxacin, offering a broader spectrum and higher potency against many pathogens. Compared with older fluoroquinolones, it often requires once‑daily dosing and has a lower risk of certain resistance mechanisms, though safety considerations such as tendon toxicity remain similar across the class.
What are the recommended storage conditions for Levofloxacine Zentiva?+
Levofloxacine Zentiva should be stored at temperatures below 25 °C, in its original packaging, and protected from moisture and direct sunlight. Keeping the product in a dry, controlled environment helps maintain its stability and potency throughout its shelf life.
How is Levofloxacine Zentiva administered?+
Levofloxacine Zentiva is taken orally, usually with a full glass of water. It may be taken with or without food, but antacids or supplements containing aluminum, magnesium, calcium, iron, or zinc should be spaced at least two hours apart to avoid reduced absorption.
What are the most serious risks associated with Levofloxacine Zentiva?+
Serious risks include tendon rupture (especially Achilles tendon), QT interval prolongation leading to cardiac arrhythmias, severe allergic reactions such as anaphylaxis, and Clostridioides difficile‑associated colitis. Patients should be advised to seek immediate medical attention if they experience sudden tendon pain, palpitations, severe rash, or persistent diarrhea.
Who should not use Levofloxacine Zentiva?+
Levofloxacine Zentiva is contraindicated in patients with a known hypersensitivity to levofloxacin, other fluoroquinolones, or any of the product excipients. It should also be avoided in individuals with a history of tendon disorders related to fluoroquinolone use, and in patients with established QT prolongation unless benefits outweigh risks.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Levofloxacin Hemihydrate
Route
Oral Use
Manufacturer
Zentiva France
Origin
EU

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