GNH USA

Europe — EMA

Levofloxacine Kabi (Levofloxacin Hemihydrate)

GNH USA supplies Levofloxacine Kabi (Levofloxacin), a fluoroquinolone for pneumonia, urinary tract, skin and sinus infections. Request a quote for supply.

Levofloxacin Hemihydrate

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What is Levofloxacin Hemihydrate?

Levofloxacin Hemihydrate, the active ingredient in Levofloxacine Kabi, is a fluoroquinolone presented as an injectable solution for intravenous use. It treats a range of serious bacterial infections, including community‑acquired pneumonia, complicated urinary tract infections, skin and soft‑tissue infections, and acute bacterial sinusitis in adult patients.

GNH USA supplies Levofloxacine Kabi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable global logistics for this critical antibacterial agent.

What is Levofloxacin Hemihydrate used for?

Levofloxacine Kabi, a fluoroquinolone antibacterial, is indicated for several serious bacterial infections.

Community‑acquired pneumonia: achieves clinical cure and bacterial eradication in adult patients. Complicated urinary tract infections: resolves infection and prevents recurrence. Skin and soft‑tissue infections: facilitates healing and eradicates causative pathogens. Acute bacterial sinusitis: improves symptoms and clears the infection.

What are the side effects of Levofloxacin Hemihydrate?

Levofloxacine Kabi may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea - Diarrhea - Headache - Rash

Serious or Rare Side Effects: - Tendon rupture or inflammation - QT interval prolongation and cardiac arrhythmias - Clostridioides difficile‑associated colitis - Severe allergic reactions including anaphylaxis

What precautions apply to Levofloxacin Hemihydrate?

Levofloxacine Kabi requires careful use in several clinical situations.

Renal impairment: adjust dose based on creatinine clearance. Known hypersensitivity: avoid use in patients allergic to levofloxacin or other fluoroquinolones. Cardiac risk: monitor QT interval in patients with existing prolongation or receiving other QT‑prolonging drugs. Tendon disorders: discontinue if tendon pain, swelling, or inflammation occurs. Elderly patients: use with caution due to increased risk of CNS effects. Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

What does Levofloxacin Hemihydrate interact with?

Levofloxacine Kabi can interact with several medicines; some combinations should be avoided while others need monitoring.

Major Interactions (Avoid): - Antacids or supplements containing magnesium or aluminum: reduce levofloxacin absorption. - Warfarin: may increase INR and bleeding risk. - Theophylline: may raise theophylline plasma concentrations.

Moderate Interactions (Monitor Closely): - NSAIDs: increased risk of CNS stimulation. - Corticosteroids: heightened risk of tendon rupture. - Other QT‑prolonging agents: monitor ECG for arrhythmias.

Frequently asked questions

What is Levofloxacine Kabi used for?+
Levofloxacine Kabi is an intravenous fluoroquinolone antibiotic indicated for the treatment of adult patients with community‑acquired pneumonia, complicated urinary tract infections, skin and soft‑tissue infections, and acute bacterial sinusitis. It is prescribed when a broad‑spectrum antibacterial agent is required.
How does levofloxacin work?+
Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes that control DNA supercoiling and replication. By blocking these targets, the drug prevents bacterial DNA synthesis and transcription, leading to rapid bacterial cell death.
What is the usual dose of Levofloxacine Kabi?+
The specific dose of Levofloxacine Kabi is determined by the prescribing clinician based on the type and severity of infection, patient weight, renal function, and other clinical factors. No fixed regimen is provided here; the prescriber sets the appropriate dosing schedule.
Is Levofloxacine Kabi safe during pregnancy or breastfeeding?+
Levofloxacine Kabi falls under an unknown pregnancy category, and safety data are limited. It should be used during pregnancy or lactation only if the potential benefits outweigh the potential risks, and after a thorough risk‑benefit assessment by the treating physician.
How do I order Levofloxacine Kabi from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.
How does Levofloxacine Kabi compare with other fluoroquinolones?+
Levofloxacine Kabi contains levofloxacin, the L‑isomer of ofloxacin, offering a broader spectrum and higher potency against many Gram‑negative and Gram‑positive pathogens compared with older agents such as ciprofloxacin. It also provides a more favorable dosing schedule for intravenous therapy, though safety considerations remain similar across the class.
What are the storage and handling requirements for Levofloxacine Kabi?+
Levofloxacine Kabi should be stored at 2‑8 °C in a refrigerator. Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking the solution. Do not use the product if it has been exposed to temperatures outside this range.
How is Levofloxacine Kabi administered?+
Levofloxacine Kabi is given as an intravenous infusion. The injectable solution is reconstituted according to the manufacturer's instructions and administered over the recommended infusion time, typically under the supervision of a qualified healthcare professional.
What are the most serious risks associated with Levofloxacine Kabi?+
Serious adverse events include tendon rupture or inflammation, QT interval prolongation leading to potentially life‑threatening arrhythmias, Clostridioides difficile‑associated colitis, severe allergic reactions such as anaphylaxis, and peripheral neuropathy. Patients should be monitored closely for any signs of these conditions.
Who should not use Levofloxacine Kabi?+
Levofloxacine Kabi is contraindicated in individuals with a known hypersensitivity to levofloxacin, other fluoroquinolones, or any component of the formulation. It should also be avoided in patients with a history of tendon disorders related to fluoroquinolone use, uncontrolled arrhythmias, or severe renal impairment without dose adjustment.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Levofloxacin Hemihydrate
Route
Intravenous Use
Manufacturer
Fresenius Kabi France S.A.S.
Origin
EU

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