Levofloxacin Krka

Levofloxacin, the active ingredient in Levofloxacin Krka, is a fluoroquinolone antibiotic presented as an oral dosage form for oral use. It treats a range of bacterial infections, including community‑acquired respiratory tract infections, urinary tract infections, skin and soft‑tissue infections, acute bacterial sinusitis, and acute bacterial prostatitis in adult patients.

GNH USA supplies Levofloxacin Krka as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides reliable global distribution.

Levofloxacin is indicated for several bacterial infections affecting the respiratory, urinary, and skin systems.

Community‑acquired respiratory tract infections: achieves bacterial eradication and clinical cure. Urinary tract infections: eliminates causative pathogens and resolves symptoms. Skin and soft‑tissue infections: provides rapid bacterial clearance and promotes healing. Acute bacterial sinusitis: clears infection and restores sinus ventilation. Acute bacterial prostatitis: eradicates prostate infection and improves urinary function.

Levofloxacin may cause a variety of adverse reactions, ranging from mild to severe.

Common Side Effects: - Nausea - Diarrhea - Headache - Dizziness

Serious or Rare Side Effects: - Tendon rupture or tendonitis - QT interval prolongation - Clostridioides difficile‑associated colitis - Severe allergic reactions (anaphylaxis) - Peripheral neuropathy - Hepatic dysfunction

When prescribing Levofloxacin, clinicians should consider several safety precautions to minimize risk.

Assess renal function: adjust dose in patients with impaired clearance. Avoid in known tendon disorders: increased risk of tendon rupture. Monitor cardiac status: risk of QT prolongation, especially with other QT‑prolonging agents. Use cautiously in the elderly: higher incidence of adverse events. Avoid concomitant NSAIDs: combined use may potentiate tendon toxicity. Store at room temperature: keep in original packaging, protect from moisture.

Levofloxacin can interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid): - Antacids or supplements containing aluminum, magnesium, calcium, or iron: reduce levofloxacin absorption. - Warfarin: may increase INR and bleeding risk. - Theophylline: elevated plasma levels can cause toxicity. - NSAIDs: combined use raises risk of tendon injury.

Moderate Interactions (Monitor Closely): - Oral contraceptives: reduced effectiveness, consider backup method. - Diabetic agents (insulin, sulfonylureas): enhanced hypoglycemic effect. - Corticosteroids: additive risk of tendon rupture.