Levofloxacin Krka

Levofloxacin, the active ingredient in Levofloxacin Krka, is a Fluoroquinolone presented as a tablet for oral use. It treats a range of bacterial infections in adults, including respiratory, urinary and skin infections, by targeting bacterial DNA replication.

GNH USA supplies Levofloxacin Krka as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance across EU markets. The product meets European pharmacopoeia standards and is available for bulk and unit‑dose distribution.

Levofloxacin is a fluoroquinolone antibiotic indicated for several bacterial infections affecting the respiratory, urinary and integumentary systems.

- Community‑acquired pneumonia: eradicates susceptible pathogens to improve respiratory function and reduce fever. - Acute bacterial sinusitis: clears sinus infection and relieves congestion and facial pain. - Acute exacerbation of chronic bronchitis: reduces bacterial load, aiding recovery of lung function. - Uncomplicated urinary tract infections: eliminates causative bacteria, restoring normal urinary symptoms. - Complicated urinary tract infections: provides broad‑spectrum coverage for resistant organisms. - Skin and soft tissue infections: treats cellulitis and wound infections caused by susceptible strains.

Levofloxacin may cause a range of adverse reactions, which are categorized by frequency.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Diarrhea: loose stools that may be watery. - Headache: transient cranial discomfort. - Rash: mild skin erythema or itching.

Serious or Rare Side Effects: - Tendon rupture: sudden tendon pain or swelling, especially in the Achilles. - QT interval prolongation: risk of cardiac arrhythmias. - Severe allergic reaction: anaphylaxis, angioedema, or Stevens‑Johnson syndrome.

Before prescribing Levofloxacin, clinicians should consider several precautionary measures to minimize risk.

- Assess renal function: adjust dosage in patients with reduced clearance. - Evaluate cardiac history: avoid in patients with known QT prolongation. - Avoid concurrent corticosteroid therapy: increased tendon rupture risk. - Monitor for tendon pain: discontinue if symptoms appear. - Check for hypersensitivity: discontinue if severe allergic reaction occurs. - Store at ambient temperature below 25°C: keep in original container, protect from moisture.

Levofloxacin can interact with other medicines, requiring attention to avoid clinically significant effects.

Major Interactions (Avoid): - Antacids containing aluminum or magnesium: reduce levofloxacin absorption. - Warfarin: may enhance anticoagulant effect and increase bleeding risk. - Drugs that prolong QT interval: additive risk of cardiac arrhythmias.

Moderate Interactions (Monitor Closely): - NSAIDs: may increase central nervous system side effects. - Theophylline: levofloxacin can raise plasma theophylline concentrations, requiring monitoring.