Levofloxacin Kabi

Levofloxacin, the active ingredient in Levofloxacin Kabi, is a fluoroquinolone presented as an injectable solution for intravenous use. It treats a range of bacterial infections in adults and children as prescribed by a healthcare professional.

GNH USA supplies Levofloxacin Kabi as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Levofloxacin is a fluoroquinolone antibiotic used to treat infections caused by susceptible bacteria.

Community-acquired pneumonia: effective therapy to eradicate the causative bacterial pathogens and improve clinical outcomes. Complicated urinary tract infections: eradicates Gram‑negative and Gram‑positive organisms, facilitating resolution of infection. Skin and soft tissue infections: provides rapid bacterial clearance and promotes wound healing. Acute bacterial sinusitis: reduces bacterial load and alleviates sinus inflammation. Acute exacerbations of chronic bronchitis: shortens symptom duration and prevents further pulmonary deterioration.

Levofloxacin may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Nausea or vomiting - Diarrhea or loose stools - Headache or dizziness - Rash or mild skin irritation - Elevated liver enzymes - Transient increase in serum creatinine

Serious or Rare Side Effects: - Tendon rupture or tendonitis, especially in the Achilles tendon - QT interval prolongation leading to cardiac arrhythmias - Clostridioides difficile‑associated colitis - Severe hypersensitivity reactions such as Stevens‑Johnson syndrome - Peripheral neuropathy or central nervous system effects

Levofloxacin should be used with caution in specific patient populations and clinical situations.

Renal impairment: adjust dose or monitor renal function closely. History of tendon disorders: avoid use due to risk of tendon rupture. QT prolongation risk: avoid in patients with known cardiac arrhythmias or electrolyte disturbances. Concurrent NSAIDs or corticosteroids: monitor for additive CNS or tendon toxicity. Pregnancy and lactation: prescribe only if potential benefit outweighs potential risk. Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Levofloxacin can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid): - Other fluoroquinolones or quinolone‑containing products: additive risk of QT prolongation. - Anti‑arrhythmic agents (e.g., sotalol, amiodarone): may precipitate serious cardiac rhythm disturbances. - Antacids or supplements containing magnesium, aluminum, calcium, or iron: markedly reduce levofloxacin absorption.

Moderate Interactions (Monitor Closely): - Warfarin: may enhance anticoagulant effect, requiring INR monitoring. - Theophylline: levofloxacin can increase serum theophylline levels, risking toxicity. - NSAIDs: combined use may increase risk of CNS stimulation and seizures. - Corticosteroids: concurrent therapy may raise the likelihood of tendon injury.