Levofloxacin Kabi

Levofloxacin, the active ingredient in Levofloxacin Kabi, is a fluoroquinolone antibiotic presented as an injectable solution for intravenous use. It treats a range of bacterial infections such as community‑acquired pneumonia, hospital‑acquired pneumonia, complicated urinary tract infections, acute bacterial sinusitis, acute bacterial exacerbation of chronic bronchitis, and skin and soft‑tissue infections in adult patients.

GNH USA supplies Levofloxacin Kabi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Levofloxacin is a fluoroquinolone antibacterial indicated for several serious bacterial infections. - Community‑acquired pneumonia: effective treatment of infection caused by susceptible bacteria. - Hospital‑acquired pneumonia: eradicates pathogens responsible for nosocomial lung infection. - Complicated urinary tract infection: clears bacterial colonisation in the urinary system. - Acute bacterial sinusitis: resolves sinus inflammation due to susceptible organisms. - Acute bacterial exacerbation of chronic bronchitis: reduces bacterial load during flare‑ups. - Skin and soft‑tissue infections: eliminates causative bacteria in dermal and subdermal tissues.

Levofloxacin may cause a variety of adverse reactions, ranging from mild to severe.

Common Side Effects: - Nausea - Diarrhoea - Headache - Dizziness - Rash - Elevated liver enzymes

Serious or Rare Side Effects: - Tendon rupture or tendinitis - QT interval prolongation and cardiac arrhythmias - Clostridioides difficile‑associated colitis - Severe hypersensitivity reactions (anaphylaxis, Stevens‑Johnson syndrome) - Hepatic toxicity - Central nervous system effects such as seizures

Levofloxacin requires careful consideration of patient‑specific factors before use. - Renal impairment: dose adjustment may be necessary based on creatinine clearance. - History of tendon disorders: avoid use in patients with prior tendon injury. - QT prolongation risk: monitor ECG in patients with cardiac arrhythmias. - Concomitant use with NSAIDs: increased risk of central nervous system side effects. - Pregnancy and lactation: safety not established; use only if clearly needed. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Levofloxacin can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid): - Warfarin: increased anticoagulant effect, risk of bleeding. - Theophylline: elevated plasma concentrations, potential toxicity. - Antacids containing magnesium or aluminum: reduced levofloxacin absorption.

Moderate Interactions (Monitor Closely): - NSAIDs: may increase risk of central nervous system adverse effects. - Corticosteroids: heightened risk of tendon rupture.