Levofloxacin Hikma Farmaceutica

Levofloxacin, the active ingredient in Levofloxacin Hikma Farmaceutica, is a fluoroquinolone antibiotic presented as an injectable solution for intravenous use. It treats a range of bacterial infections in adults and children as prescribed.

GNH USA supplies Levofloxacin Hikma Farmaceutica as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Levofloxacin is a fluoroquinolone antibiotic used to treat infections caused by susceptible bacteria.

- Community-acquired pneumonia: eradicates the causative bacteria, leading to clinical improvement and resolution of infection. - Hospital-acquired pneumonia: eliminates pathogenic organisms, facilitating recovery in hospitalized patients. - Acute bacterial sinusitis: clears sinus infection, reducing symptoms and preventing complications. - Acute bacterial exacerbation of chronic bronchitis: controls bacterial flare‑ups, improving breathing function. - Skin and soft tissue infections: destroys skin‑associated bacteria, promoting wound healing. - Urinary tract infections: removes uropathogens, restoring urinary health.

Levofloxacin may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Nausea: mild gastrointestinal upset occurring shortly after infusion. - Diarrhea: loose stools that may be self‑limiting. - Headache: transient cranial discomfort. - Dizziness: occasional light‑headed sensation.

Serious or Rare Side Effects: - Tendon rupture: sudden tendon pain or rupture, especially in the Achilles. - QT interval prolongation: risk of cardiac arrhythmias. - Severe allergic reactions: anaphylaxis, rash, or angioedema. - Clostridioides difficile‑associated diarrhea: severe colitis requiring medical attention.

Before initiating therapy, consider the following precautions.

- Renal function assessment: adjust dosing in patients with impaired kidney function. - Hypersensitivity screening: avoid use in individuals with known allergy to fluoroquinolones. - QT prolongation risk: use cautiously in patients with cardiac conduction disorders. - Tendon monitoring: advise patients to report tendon pain or swelling promptly. - Concomitant QT‑prolonging drugs: evaluate drug regimen to minimize additive effects. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Levofloxacin can interact with several medications; awareness of interaction severity is essential.

Major Interactions (Avoid): - Antacids containing aluminum or magnesium: reduce levofloxacin absorption, diminishing efficacy. - Warfarin: may increase INR and bleeding risk. - Theophylline: can raise theophylline plasma levels, leading to toxicity.

Moderate Interactions (Monitor Closely): - Corticosteroids: combined use raises the risk of tendon rupture. - Diabetic agents (e.g., insulin, sulfonylureas): may potentiate hypoglycemia. - Other QT‑prolonging agents: monitor cardiac rhythm closely.