GNH USA

Europe — EMA

Levofloxacin Accord Healthcare

GNH USA supplies Levofloxacin Accord Healthcare (Levofloxacin), a fluoroquinolone antibiotic for respiratory, urinary and skin infections. Request a quote.

Levofloxacin Hemihydrate

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What is Levofloxacin Hemihydrate?

Levofloxacin, the active ingredient in Levofloxacin Accord Healthcare, is a fluoroquinolone antibiotic presented as an oral tablet for systemic use. It treats a range of bacterial infections in adults and children when prescribed by a qualified health professional.

GNH USA supplies Levofloxacin Accord Healthcare as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Levofloxacin Hemihydrate used for?

Levofloxacin is a broad‑spectrum antibacterial that targets common bacterial pathogens in several organ systems. - Community‑acquired respiratory tract infections: eradicates susceptible organisms and improves cough, sputum and fever. - Acute bacterial sinusitis: reduces sinus inflammation and clears infection. - Acute exacerbations of chronic bronchitis: shortens symptom duration and prevents complications. - Urinary tract infections: eliminates causative bacteria and relieves dysuria. - Skin and soft‑tissue infections: treats cellulitis, abscesses and other bacterial skin conditions.

What are the side effects of Levofloxacin Hemihydrate?

Levofloxacin may cause a variety of adverse reactions, ranging from mild to severe.

Common Side Effects: - Nausea: mild to moderate gastrointestinal upset. - Diarrhea: loose stools, sometimes watery. - Headache: transient cranial discomfort. - Dizziness: occasional vertigo or light‑headedness. - Rash: mild skin erythema or itching.

Serious or Rare Side Effects: - Tendon rupture: sudden pain and loss of function, especially in the Achilles. - QT prolongation: cardiac rhythm disturbances that may cause palpitations. - Severe allergic reaction: anaphylaxis with swelling, breathing difficulty. - Central nervous system effects: seizures or severe confusion. - Liver injury: jaundice or elevated liver enzymes.

What precautions apply to Levofloxacin Hemihydrate?

Before prescribing Levofloxacin, clinicians should consider several safety factors. - Renal impairment: adjust dose or monitor renal function closely. - History of tendon disorders: avoid use in patients with prior tendon injury. - Cardiac risk: assess QT interval in patients with known arrhythmias. - Pregnancy and lactation: use only if benefits outweigh potential risks, as safety data are limited. - Concomitant CNS active drugs: monitor for increased neurotoxicity. - Store below 25°C: keep in the original container, protect from moisture and heat.

What does Levofloxacin Hemihydrate interact with?

Levofloxacin can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid): - Antacids containing aluminum or magnesium: markedly reduce levofloxacin absorption. - Warfarin: may increase anticoagulant effect and bleeding risk. - NSAIDs (e.g., ibuprofen): heighten risk of central nervous system stimulation.

Moderate Interactions (Monitor Closely): - Theophylline: may raise serum theophylline levels, requiring dose adjustment. - Corticosteroids: increase risk of tendon rupture. - Diabetic agents: potential for altered glucose control.

Frequently asked questions

What infections is Levofloxacin Accord Healthcare used to treat?+
Levofloxacin Accord Healthcare is indicated for a range of bacterial infections, including community‑acquired respiratory tract infections, acute bacterial sinusitis, acute exacerbations of chronic bronchitis, urinary tract infections, and skin and soft‑tissue infections. It is prescribed when the causative bacteria are known or suspected to be susceptible to fluoroquinolones.
How does levofloxacin work against bacteria?+
Levofloxacin works by binding to bacterial DNA gyrase and topoisomerase IV, enzymes that control DNA supercoiling and replication. Inhibiting these enzymes stops bacterial DNA synthesis and transcription, leading to rapid bacterial cell death. This mechanism gives levofloxacin broad‑spectrum activity against many Gram‑negative and Gram‑positive organisms.
What is the usual dose of Levofloxacin Accord Healthcare?+
The dosage of Levofloxacin Accord Healthcare is determined by the prescribing clinician based on the infection type, severity, patient age, renal function and other clinical factors. Healthcare professionals select the appropriate strength, frequency and duration according to approved labeling and local guidelines.
Is Levofloxacin safe to use during pregnancy or breastfeeding?+
Safety data for levofloxacin in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.
How do I order Levofloxacin Accord Healthcare from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and assistance with import documentation.
How does Levofloxacin compare with other fluoroquinolones?+
Levofloxacin is the L‑isomer of ofloxacin and generally offers higher potency and better tissue penetration than many older fluoroquinolones. Compared with ciprofloxacin, it often requires once‑daily dosing and has a broader spectrum against Gram‑positive organisms, while maintaining similar activity against Gram‑negative bacteria.
What are the recommended storage conditions for Levofloxacin Accord Healthcare?+
Levofloxacin Accord Healthcare tablets should be stored below 25 °C in a dry place. Keep them in the original blister pack or container, protect from moisture and direct sunlight, and ensure they are out of reach of children.
How is Levofloxacin Accord Healthcare administered?+
Levofloxacin Accord Healthcare is administered orally, usually as a tablet taken with a full glass of water. It may be taken with or without food, but patients should avoid taking it simultaneously with antacids containing aluminum or magnesium, as these can reduce absorption.
What are the most serious risks associated with Levofloxacin?+
The most serious risks include tendon rupture (especially Achilles), QT interval prolongation leading to cardiac arrhythmias, severe allergic reactions such as anaphylaxis, and central nervous system effects like seizures. Patients should be advised to seek immediate medical attention if they experience sudden tendon pain, palpitations, rash, or neurological symptoms.
Who should not take Levofloxacin Accord Healthcare?+
Levofloxacin should be avoided in patients with a known hypersensitivity to fluoroquinolones, a history of tendon disorders related to quinolone use, or those taking medications that significantly prolong the QT interval. Caution is also advised for individuals with severe renal impairment, uncontrolled epilepsy, or pregnant women unless clearly indicated.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.

Product details

Drug
Levofloxacin Hemihydrate
Route
Oral Use
Manufacturer
Accord Healthcare Limited
Origin
EU

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