Levofloxacin Hikma Farmacêutica (Portugal)

Levofloxacin, the active ingredient in Levofloxacin Hikma Farmacêutica (Portugal), is a fluoroquinolone antibiotic presented as a intravenous solution for parenteral use. It treats a range of bacterial infections in adults, including pneumonia, urinary tract infections, skin and soft‑tissue infections, and intra‑abdominal infections.

GNH USA supplies Levofloxacin Hikma Farmacêutica (Portugal) as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Levofloxacin is a fluoroquinolone antibiotic used to treat bacterial infections affecting various organ systems. - Community‑acquired pneumonia: effective in achieving clinical cure and bacterial eradication. - Hospital‑acquired pneumonia: used to obtain microbiological clearance in severe cases. - Urinary tract infections: facilitates resolution of infection and symptom relief. - Skin and soft‑tissue infections: promotes healing by eliminating causative bacteria. - Intra‑abdominal infections: assists in controlling polymicrobial infection and preventing complications.

Levofloxacin may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea: mild gastrointestinal upset. - Diarrhea: loose stools, often self‑limiting. - Headache: transient cranial discomfort. - Dizziness: occasional balance disturbances. - Rash: mild skin erythema.

Serious or Rare Side Effects: - Tendon rupture: sudden tendon pain or rupture, especially Achilles. - QT prolongation: cardiac rhythm disturbances requiring monitoring. - Severe allergic reaction: anaphylaxis or angioedema. - Clostridioides difficile colitis: severe diarrhea due to gut flora disruption.

When prescribing Levofloxacin, clinicians should consider several safety and handling precautions. - Renal impairment: adjust therapy based on renal function. - History of tendon disorders: avoid use in patients with prior tendon injury. - Cardiac risk: monitor QT interval in patients with known prolongation. - Concomitant CNS active drugs: use caution with drugs that may lower seizure threshold. - Pregnancy and lactation: avoid unless benefit outweighs risk, as safety data are limited. - Store at ambient temperature: keep below 25 °C, protect from moisture and light in original packaging.

Levofloxacin can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid): - Antacids containing aluminum or magnesium: reduce absorption, separate dosing by at least 2 hours. - Warfarin: may increase INR, require close coagulation monitoring. - Cyclosporine: increased cyclosporine levels, monitor renal function.

Moderate Interactions (Monitor Closely): - NSAIDs: heightened risk of CNS stimulation or seizures. - Theophylline: possible increased serum theophylline concentrations. - Diabetic agents (insulin, sulfonylureas): may cause hypoglycemia, monitor glucose.