Levofloxacin

Levofloxacin, the active ingredient in Levofloxacin, is a fluoroquinolone antibiotic presented as a solution for injection for intravenous use. It treats a range of bacterial infections in adults and children as prescribed.

GNH USA supplies Levofloxacin as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Levofloxacin is indicated for several bacterial infections affecting respiratory, urinary, skin, and intra‑abdominal systems.

Community‑acquired pneumonia: eradicates the causative bacteria, improving respiratory function. Acute bacterial sinusitis: resolves sinus infection and relieves congestion. Acute bacterial exacerbation of chronic bronchitis: reduces bacterial load and shortens symptom duration. Skin and soft tissue infections: eliminates pathogenic bacteria, promoting wound healing. Urinary tract infections: clears urinary pathogens, relieving dysuria and frequency. Prostatitis: treats bacterial prostatitis, alleviating pelvic pain and urinary symptoms. Intra‑abdominal infections: controls polymicrobial infection, supporting recovery after surgery.

Levofloxacin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea: mild gastrointestinal upset. - Diarrhea: loose stools, sometimes watery. - Headache: transient cranial discomfort. - Dizziness: occasional vertigo or light‑headedness. - Rash: mild skin erythema.

Serious or Rare Side Effects: - Tendon rupture: especially Achilles, may occur during or after therapy. - QT prolongation: cardiac rhythm disturbance requiring monitoring. - Severe hypersensitivity: anaphylaxis or Stevens‑Johnson syndrome. - Clostridioides difficile colitis: severe intestinal infection. - Central nervous system effects: seizures or psychosis.

When prescribing Levofloxacin, clinicians should consider several safety and handling precautions. - Renal impairment: adjust dose or monitor renal function. - History of tendon disorders: avoid use or monitor for pain. - Cardiac arrhythmias: avoid in patients with QT prolongation risk. - Concomitant CNS active drugs: monitor for seizures or confusion. - Pregnancy and lactation: use only if benefits outweigh risks, as safety is unknown. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Levofloxacin can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid): - Antacids containing aluminum or magnesium: reduce absorption; separate dosing by at least 2 hours. - Warfarin: may increase INR, requiring closer monitoring. - NSAIDs (e.g., ibuprofen): heightened risk of CNS stimulation and seizures.

Moderate Interactions (Monitor Closely): - Theophylline: may increase serum levels, watch for toxicity. - Cyclosporine: increased cyclosporine concentrations, monitor levels. - Diabetic agents (e.g., insulin, sulfonylureas): may cause hypoglycemia, monitor glucose.