GNH USA

Europe — EMA

Levodopa/Carbidopa/Entacapone Teva

GNH USA supplies Levodopa/Carbidopa/Entacapone (Levodopa combo), a antiparkinson agent for Parkinson's disease and motor fluctuation management.

Carbidopa, Entacapone, Levodopa

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What is Carbidopa, Entacapone, Levodopa?

Levodopa/Carbidopa/Entacapone, the active ingredient in Levodopa/Carbidopa/Entacapone Teva, is an antiparkinson agent presented as an oral tablet for oral use. It is indicated for the symptomatic treatment of Parkinson's disease and for the reduction of motor fluctuations in patients receiving levodopa therapy.

GNH USA supplies Levodopa/Carbidopa/Entacapone Teva as a licensed, GDP‑compliant international pharmaceutical supplier, delivering high‑quality generic medication to hospitals, pharmacies and clinics worldwide while ensuring consistent product quality and regulatory compliance.

What is Carbidopa, Entacapone, Levodopa used for?

Levodopa/Carbidopa/Entacapone acts within the dopaminergic pathway to improve motor control in Parkinsonian disorders. - Parkinson's disease: improves bradykinesia, rigidity and tremor. - Motor fluctuations in Parkinson's disease: reduces "off" periods and prolongs "on" time. - Early-stage Parkinson's disease: provides smoother dopamine levels to delay progression of motor complications.

What are the side effects of Carbidopa, Entacapone, Levodopa?

Levodopa/Carbidopa/Entacapone may cause a range of adverse reactions.

Common Side Effects: - Nausea: mild to moderate gastrointestinal upset. - Dizziness: often related to orthostatic changes. - Orthostatic hypotension: drop in blood pressure upon standing. - Dry mouth: reduced salivation.

Serious or Rare Side Effects: - Dyskinesia: involuntary, erratic movements. - Hallucinations: visual or auditory perceptual disturbances. - Severe psychiatric reactions: including psychosis or severe depression.

What precautions apply to Carbidopa, Entacapone, Levodopa?

Use of Levodopa/Carbidopa/Entacapone requires careful monitoring. - Blood pressure monitoring: watch for orthostatic hypotension. - Psychiatric assessment: observe for hallucinations or mood changes. - Renal function: dose may need adjustment in severe impairment. - Abrupt discontinuation: avoid sudden stop to prevent withdrawal symptoms. - Elderly patients: start at low dose and titrate slowly. - Store at ambient temperature: keep in the original container, protect from moisture.

What does Carbidopa, Entacapone, Levodopa interact with?

Levodopa/Carbidopa/Entacapone interacts with several drug classes.

Major Interactions (Avoid): - Non‑selective MAO inhibitors: risk of hypertensive crisis. - Antipsychotics (e.g., haloperidol): may diminish antiparkinson effect. - Antihypertensives: can exacerbate hypotension.

Moderate Interactions (Monitor Closely): - SSRIs and SNRIs: potential for serotonin syndrome. - Iron or calcium supplements: may reduce levodopa absorption. - Anticholinergics: can increase central side effects.

Frequently asked questions

What is Levodopa/Carbidopa/Entacapone used for?+
Levodopa/Carbidopa/Entacapone is prescribed to treat the motor symptoms of Parkinson's disease and to manage motor fluctuations, such as "off" periods, in patients already receiving levodopa therapy. It helps improve movement, reduce rigidity, and control tremor.
How does Levodopa/Carbidopa/Entacapone work?+
The combination works by delivering levodopa, which is converted to dopamine in the brain, while carbidopa prevents its breakdown outside the central nervous system, increasing brain availability. Entacapone further inhibits the COMT enzyme, prolonging levodopa's plasma half‑life and enhancing its therapeutic effect.
What is the usual dose of Levodopa/Carbidopa/Entacapone?+
The specific dose and dosing schedule are determined by the prescribing clinician based on the individual patient's disease stage, response to therapy, and tolerability. Patients should follow the prescriber's instructions and not adjust the dose without medical guidance.
Is Levodopa/Carbidopa/Entacapone safe during pregnancy or breastfeeding?+
Safety data for use in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and decisions should be made in consultation with a healthcare professional.
How do I order Levodopa/Carbidopa/Entacapone from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Levodopa/Carbidopa/Entacapone compare with other Parkinson's medications?+
Compared with levodopa alone, the addition of carbidopa reduces peripheral side effects and increases central availability, while entacapone extends levodopa's half‑life, offering more stable symptom control. It is often preferred over single‑component regimens for patients experiencing motor fluctuations.
What are the storage requirements for Levodopa/Carbidopa/Entacapone?+
Store the tablets at ambient temperature, preferably below 25 °C. Keep them in the original packaging to protect from moisture and light. Do not store in humid or excessively hot environments to maintain product stability.
How is Levodopa/Carbidopa/Entacapone administered?+
Levodopa/Carbidopa/Entacapone is taken orally, usually with a glass of water. It may be taken with or without food, but consistent timing relative to meals can help reduce gastrointestinal side effects. Follow the prescriber's instructions regarding dosing intervals.
What are the most serious risks associated with Levodopa/Carbidopa/Entacapone?+
Serious risks include the development of dyskinesia (involuntary movements), hallucinations, and severe psychiatric reactions such as psychosis. Patients should be monitored closely for these effects, and any sudden changes in behavior or movement should be reported to a healthcare professional immediately.
Who should not use Levodopa/Carbidopa/Entacapone?+
Patients with known hypersensitivity to levodopa, carbidopa, entacapone, or any excipients should avoid the product. It is also contraindicated in individuals taking non‑selective MAO inhibitors. Caution is advised in patients with severe cardiovascular disease, narrow‑angle glaucoma, or a history of severe psychiatric disorders.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Carbidopa, Entacapone, Levodopa
Route
Oral Use
Manufacturer
Teva Italia S.R.L.
Origin
EU

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