Europe — EMA
Levodopa/Carbidopa/Entacapona Cinfa (Carbidopa, Entacapone, Levodopa)
GNH USA supplies Levodopa/Carbidopa/Entacapone (Levodopa/Carbidopa/Entacapone), a antiparkinson agent for Parkinson's disease.
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What is Carbidopa, Entacapone, Levodopa?
Levodopa/Carbidopa/Entacapone, the active ingredient in Levodopa/Carbidopa/Entacapone Cinfa, is an antiparkinson agent presented as an oral tablet for oral use. It is used to manage Parkinson's disease symptoms in adults, particularly when motor fluctuations occur during levodopa therapy.
GNH USA supplies Levodopa/Carbidopa/Entacapone Cinfa as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.
What is Carbidopa, Entacapone, Levodopa used for?
Levodopa/Carbidopa/Entacapone is an antiparkinson combination that targets dopamine deficiency in Parkinson's disease.
- Parkinson's disease (motor fluctuations): improves overall motor control and reduces "off" periods. - Parkinson's disease (early morning akinesia): lessens stiffness and difficulty initiating movement. - Parkinson's disease (advanced stage): enhances the effectiveness of levodopa therapy and smooths symptom control.
What are the side effects of Carbidopa, Entacapone, Levodopa?
Levodopa/Carbidopa/Entacapone may cause a range of adverse reactions.
Common Side Effects: - Nausea: mild to moderate gastrointestinal upset. - Dizziness: often related to orthostatic changes. - Headache: transient and usually resolves. - Insomnia: difficulty falling or staying asleep. - Orthostatic hypotension: drop in blood pressure upon standing. - Dry mouth: reduced salivation.
Serious or Rare Side Effects: - Dyskinesia: involuntary, erratic movements. - Severe hypotension: may lead to fainting. - Psychiatric disturbances: hallucinations or confusion. - Cardiac arrhythmias: irregular heart rhythms. - Neuroleptic malignant syndrome: rare but life‑threatening reaction. - Severe allergic reactions: rash, swelling, or breathing difficulty.
What precautions apply to Carbidopa, Entacapone, Levodopa?
Patients should be evaluated for specific health conditions before initiating therapy.
- Renal impairment: adjust dosing and monitor renal function. - Hepatic impairment: use with caution; monitor liver enzymes. - Cardiovascular disease: watch for hypotension and arrhythmias. - Psychiatric history: assess risk of hallucinations or confusion. - Pregnancy and lactation: only use if benefits outweigh risks; consult a specialist. - Storage: Store at ambient temperature below 25 °C: keep in the original container, protect from moisture and light.
What does Carbidopa, Entacapone, Levodopa interact with?
Levodopa/Carbidopa/Entacapone can interact with several drug classes.
Major Interactions (Avoid): - Non‑selective MAO inhibitors: risk of hypertensive crisis. - Antipsychotics (especially dopamine antagonists): may diminish therapeutic effect. - High‑dose pyridoxine (vitamin B6): interferes with levodopa conversion. - Certain antihypertensives (e.g., alpha‑blockers): may exacerbate hypotension. - SSRIs or SNRIs: increase risk of serotonin syndrome.
Moderate Interactions (Monitor Closely): - Other dopaminergic agents: may increase dyskinesia. - Anticholinergic drugs: additive central nervous system effects. - Iron or calcium supplements: reduce levodopa absorption. - Protein‑rich meals: compete with levodopa for transport across the gut. - Diuretics: may affect electrolyte balance and blood pressure.
