Leverette 28 (Ethinylestradiol, Levonorgestrel | Lactose)

Ethinylestradiol, the active ingredient in Leverette 28, is a combined oral contraceptive presented as a tablet for oral use. It prevents pregnancy in women of reproductive age. Leverette 28 also contains levonorgestrel, a progestogenic component that enhances contraceptive efficacy.

GNH USA supplies Leverette 28 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Leverette 28 is a combined oral contraceptive that acts on the hormonal regulation of the menstrual cycle to prevent unintended pregnancy. - Contraception: prevents pregnancy in women of reproductive age. - Menstrual cycle regulation: helps establish a regular monthly bleeding pattern. - Acne management: may improve hormonal acne in some users.

Leverette 28 may cause a range of adverse reactions. Patients should be aware of both common and serious possibilities.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Headache: tension‑type or migraine‑like pain. - Breast tenderness: swelling or discomfort of the breasts. - Spotting between periods: light vaginal bleeding.

Serious or Rare Side Effects: - Blood clots: deep vein thrombosis or pulmonary embolism. - Stroke: neurological deficits due to cerebrovascular occlusion. - Severe allergic reaction: rash, swelling, or anaphylaxis.

Before prescribing Leverette 28, clinicians should evaluate individual risk factors and advise patients accordingly. - Assess thromboembolic risk: review personal and family history of clotting disorders. - Monitor cardiovascular health: avoid use in uncontrolled hypertension or smoking over age 35. - Evaluate hepatic function: caution in patients with liver disease. - Review medication history: certain enzyme‑inducing drugs may reduce effectiveness. - Store at room temperature below 25°C: keep in the original pack, protect from moisture and light.

Leverette 28 can interact with several drug classes, altering its contraceptive efficacy or increasing adverse effects.

Major Interactions (Avoid): - Antiepileptic enzyme inducers (e.g., phenytoin, carbamazepine, phenobarbital): markedly reduce hormone levels. - Rifampin and other strong antibiotics: decrease contraceptive effectiveness. - St. John's wort: herbal inducer that may compromise efficacy.

Moderate Interactions (Monitor Closely): - Antifungal agents (e.g., ketoconazole, itraconazole): may increase hormone concentrations. - HIV protease inhibitors (e.g., ritonavir): can affect hormone metabolism. - Certain antidepressants (e.g., SSRIs): may modestly alter plasma levels. - Ginkgo biloba: potential additive effect on bleeding risk.