Leucovorin

Folinic acid, the active ingredient in Leucovorin, is a folate analog presented as a sterile solution for intramuscular and intravenous use. It provides a reduced form of folate that bypasses dihydrofolate reductase inhibition, restoring nucleotide synthesis in normal cells. Clinically, it is employed as rescue therapy for methotrexate toxicity, as an adjunct in the treatment of selected cancers such as colorectal cancer, and for supplementation in folate deficiency.

GNH USA supplies Leucovorin as a licensed, GDP‑compliant international pharmaceutical supplier, sourcing the product from EU manufacturers and serving hospitals, oncology centres and pharmacies worldwide.

Leucovorin is a folate analog used to support folate‑dependent pathways in several clinical situations.

- Methotrexate toxicity: provides rescue therapy that reduces toxic effects of high‑dose methotrexate. - Colorectal cancer (and other selected cancers): acts as an adjunct to enhance the efficacy of fluoropyrimidine‑based chemotherapy. - Folate deficiency: supplies folate to correct deficiency and support normal cellular function.

Leucovorin may be associated with adverse reactions, which are categorized by frequency.

Common Side Effects: - Nausea - Vomiting - Mild rash or erythema - Fever - Headache - Dizziness

Serious or Rare Side Effects: - Anaphylactic reaction - Severe hypotension - Acute renal dysfunction - Hepatic toxicity - Stevens‑Johnson syndrome or toxic epidermal necrolysis - Seizures or convulsions

Leucovorin should be used with appropriate clinical monitoring and handling.

- Renal function: assess baseline renal status and monitor during therapy. - Hepatic function: evaluate liver enzymes before and during treatment. - Hypersensitivity: observe for signs of allergic reaction, especially on first administration. - Folate metabolism disorders: use with caution in patients with known enzyme deficiencies. - Elderly patients: consider reduced physiological reserve and monitor closely. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Leucovorin can interact with several medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid): - High‑dose methotrexate: concurrent use may diminish methotrexate’s antitumor activity. - Antifolate agents (e.g., pemetrexed): may antagonize therapeutic effect.

Moderate Interactions (Monitor Closely): - NSAIDs: can affect renal clearance of folinic acid. - Trimethoprim‑sulfamethoxazole: may increase folate antagonism. - Phenytoin: may alter folate metabolism, requiring monitoring. - Oral contraceptives: folinic acid may affect hormone levels, warranting observation. - Vitamin C (high dose): potential reduction of antifolate efficacy.