Leucovorin

Calcium Folinate Pentahydrate, the active ingredient in Leucovorin, is a folate analog presented as an oral formulation for systemic use. It is employed to correct folate deficiency and to mitigate toxicity from high‑dose methotrexate or certain fluoropyrimidine regimens in oncology and hematology patients.

GNH USA supplies Leucovorin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, transplant centres and pharmacies worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution, ensuring reliable supply chains and timely delivery.

Leucovorin is used to address folate‑related pathways and mitigate chemotherapy‑induced toxicity.

- Methotrexate toxicity rescue: restores folate pools to reduce hematologic and mucosal toxicity. - Adjunctive therapy after high‑dose methotrexate: supports normal cell recovery during cancer treatment. - Enhancement of 5‑fluorouracil efficacy: stabilizes intracellular folate to improve drug activity. - Folate deficiency: supplies reduced folate to patients with inadequate dietary or metabolic folate levels.

Leucovorin is generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Nausea: mild to moderate upset stomach. - Diarrhea: loose stools that may be transient. - Rash: skin redness or mild itching. - Headache: occasional dull or throbbing pain.

Serious or Rare Side Effects: - Anaphylactic reaction: severe allergic response requiring immediate medical attention. - Stevens‑Johnson syndrome: rare skin and mucous membrane disorder. - Pancytopenia: marked reduction in blood cell counts. - Hepatic dysfunction: abnormal liver enzyme elevations. - Renal failure: impaired kidney function in susceptible individuals.

Leucovorin should be used with appropriate clinical monitoring.

- Renal impairment: adjust use if kidney function is reduced. - Hepatic disease: monitor liver enzymes during therapy. - Concomitant antifolates: assess timing to avoid antagonism. - Pregnancy and lactation: safety not established; consult a physician. - Pediatric use: dose and safety require specialist oversight. - Store at ambient temperature: keep below 25 °C, in the original container, protected from moisture and direct sunlight.

Leucovorin may interact with several drug classes.

Major Interactions (Avoid): - High‑dose methotrexate: inappropriate timing can diminish rescue effect. - Other antifolates (e.g., pemetrexed): may counteract therapeutic action. - Oral contraceptives: folate supplementation can reduce contraceptive efficacy.

Moderate Interactions (Monitor Closely): - Antiepileptic drugs (phenytoin, carbamazepine): may increase folate metabolism, requiring dose review. - High‑dose vitamin C: can affect folate stability and absorption.