Leucovorin

Calcium Folinate, the active ingredient in Leucovorin, is a folate analog presented as an injectable solution for intramuscular or intravenous use. It is employed to rescue normal cells from the effects of certain chemotherapeutic agents and to prevent folate deficiency in patients receiving high‑dose methotrexate or fluorouracil‑based regimens.

GNH USA supplies Leucovorin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Leucovorin is used as a folate rescue and adjunct in oncology and supportive care. - Rescue after high‑dose methotrexate: restores folate pools to reduce toxicity. - Adjunct to fluorouracil‑based chemotherapy: enhances antitumor activity while protecting normal tissue. - Prevention of folate deficiency: supplies reduced folate to patients at risk of deficiency during chemotherapy.

Leucovorin may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects: - Nausea or vomiting - Diarrhea - Mild rash or itching - Transient elevation of liver enzymes - Low blood pressure during rapid IV infusion

Serious or Rare Side Effects: - Severe allergic reaction (anaphylaxis) - Acute renal impairment - Significant electrolyte disturbances - Hemolytic anemia in patients with G6PD deficiency

Leucovorin should be used with attention to patient‑specific factors and proper handling. - Renal function: assess before administration in patients with impaired kidneys. - Hepatic function: monitor liver enzymes during prolonged therapy. - Pregnancy: avoid unless clearly needed; risk to fetus is unknown. - Breastfeeding: consider potential excretion in milk; weigh benefits versus risks. - Concomitant methotrexate: adjust timing to avoid antagonism of therapeutic effect. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Leucovorin can interact with drugs that affect folate metabolism or renal clearance.

Major Interactions (Avoid): - High‑dose methotrexate given too close to leucovorin: may reduce antitumor efficacy. - Antifolate agents (e.g., pemetrexed) administered concurrently: potential antagonism.

Moderate Interactions (Monitor Closely): - NSAIDs: may impair renal clearance of leucovorin. - Loop diuretics: increase risk of electrolyte imbalance. - Proton pump inhibitors: may affect folate absorption indirectly.