GNH USA

Europe — EMA

Letizen S

GNH USA supplies Letizen S (Cetirizine), a second‑generation H1 antihistamine for allergic rhinitis and chronic urticaria. Request a quote for global supply.

Cetirizine Dihydrochloride

Request sourcing

1
Pack/s

What is Cetirizine Dihydrochloride?

Cetirizine, the active ingredient in Letizen S, is a second‑generation H1 antihistamine presented as an oral tablet for oral use. It is used to relieve symptoms of allergic rhinitis, seasonal and perennial allergies, and chronic idiopathic urticaria in adults and children.

GNH USA supplies Letizen S as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Cetirizine Dihydrochloride used for?

Letizen S, a second‑generation H1 antihistamine, is indicated for several allergic and hypersensitivity conditions.

Allergic rhinitis: reduces sneezing, itching, and nasal discharge. Seasonal allergic rhinitis: alleviates symptoms triggered by pollen or outdoor allergens. Perennial allergic rhinitis: controls year‑round nasal allergy symptoms. Chronic idiopathic urticaria: diminishes hives and associated itching. Other hypersensitivity reactions: mitigates skin and mucosal allergic responses.

What are the side effects of Cetirizine Dihydrochloride?

Cetirizine is generally well tolerated, but some adverse reactions may occur.

Common Side Effects: - Mild headache. - Drowsiness or fatigue (less frequent than first‑generation antihistamines). - Dry mouth. - Nausea or abdominal discomfort. - Dizziness. - Sore throat.

Serious or Rare Side Effects: - Severe allergic reaction (anaphylaxis) with rash, swelling, or difficulty breathing. - Cardiac arrhythmias in susceptible individuals. - Liver enzyme elevations. - Blood dyscrasias such as neutropenia. - Persistent tachycardia. - Severe skin reactions like Stevens‑Johnson syndrome.

What precautions apply to Cetirizine Dihydrochloride?

Before using Letizen S, consider the following precautions.

Pregnancy: Category B; discuss use with a healthcare professional. Breastfeeding: Small amounts may be excreted in milk; consult a physician. Renal impairment: Dose adjustment may be required. Elderly patients: Monitor for increased sedation. Driving or operating machinery: Caution if experiencing drowsiness. Store at ambient temperature below 25°C: keep in the original container, protect from moisture and direct sunlight.

What does Cetirizine Dihydrochloride interact with?

Cetirizine may interact with several medicines; awareness helps avoid adverse effects.

Major Interactions (Avoid): - Ketoconazole or erythromycin: may increase cetirizine plasma levels. - Theophylline: can reduce antihistamine efficacy. - Alcohol: additive CNS depression.

Moderate Interactions (Monitor Closely): - Other antihistamines: risk of additive sedation. - CNS depressants (benzodiazepines, opioids): may enhance drowsiness. - Rifampicin: may lower cetirizine concentrations.

Frequently asked questions

What conditions is Letizen S used for?+
Letizen S contains cetirizine, which is indicated for relief of symptoms associated with allergic rhinitis, both seasonal and perennial, as well as chronic idiopathic urticaria and other hypersensitivity reactions. It helps reduce sneezing, itching, nasal discharge, and hives.
How does cetirizine work in Letizen S?+
Cetirizine is a selective H1‑receptor antagonist. By blocking peripheral H1 receptors on mast cells and basophils, it prevents histamine from binding, thereby reducing vasodilation, increased vascular permeability, and the resulting allergic symptoms such as itching and swelling.
What is the usual dose of Letizen S?+
The appropriate dose of Letizen S is determined by a prescriber based on the patient’s age, condition, and clinical response. Healthcare professionals tailor the regimen to achieve optimal symptom control while minimizing potential side effects.
Is Letizen S safe to use during pregnancy or breastfeeding?+
Cetirizine is classified as Pregnancy Category B, indicating no evidence of risk in animal studies, but human data are limited. It is excreted in small amounts in breast milk, so a healthcare provider should evaluate the benefit‑risk balance before use in pregnant or nursing women.
How do I order Letizen S from GNH USA?+
To place an order, submit an enquiry on the Letizen S product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.
How does Letizen S compare with other antihistamines?+
Letizen S (cetirizine) is a second‑generation antihistamine offering effective allergy relief with a lower incidence of sedation compared with first‑generation agents like diphenhydramine. Compared with other second‑generation drugs such as loratadine, cetirizine may provide slightly faster onset of action for some patients.
What are the recommended storage conditions for Letizen S?+
Letizen S should be stored at ambient temperature below 25 °C. Keep the tablets in the original packaging, protect them from moisture, excessive heat, and direct sunlight to maintain stability and potency throughout the shelf life.
How is Letizen S administered?+
Letizen S is taken orally, usually with a glass of water. The tablet can be swallowed with or without food, unless the prescriber advises otherwise. Patients should follow the dosing instructions provided by their healthcare professional.
What are the most serious risks associated with Letizen S?+
Serious but rare risks include anaphylactic reactions, severe skin reactions such as Stevens‑Johnson syndrome, and cardiac arrhythmias in susceptible individuals. Patients should seek immediate medical attention if they experience symptoms like difficulty breathing, rash, or irregular heartbeat.
Who should not use Letizen S?+
Letizen S should be avoided in individuals with known hypersensitivity to cetirizine or any component of the formulation. Caution is also advised for patients with severe renal impairment, pregnant or nursing women without medical guidance, and those taking interacting medications without physician supervision.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
Send a sourcing enquiry for this product →

Product details

Drug
Cetirizine Dihydrochloride
Route
Oral Use
Manufacturer
Krka-Farma D.O.O.
Origin
EU

Related products

A

A

Liquid Extract From Viscum Album Subsp. Abietis Var Abies Alba (1:20), Extraction Solvents: Water Fo

Helixor Heilmittel Gmbh
EU
A

A

Liquid Extract From Viscum Album Subsp. Abietis Var Abies Alba (1:20), Extraction Solvents: Water Fo

Helixor Heilmittel Gmbh
EU
A

A

Liquid Extract From Viscum Album Subsp. Abietis Var Abies Alba (1:20), Extraction Solvents: Water Fo

Helixor Heilmittel Gmbh
EU
A

A

Liquid Extract From Viscum Album Subsp. Abietis Var Abies Alba (1:20), Extraction Solvents: Water Fo

Helixor Heilmittel Gmbh
EU