Lestedon

Dutasteride, the active ingredient in Lestedon, is a 5-alpha-reductase inhibitor presented as an oral tablet for oral use. It reduces prostate enlargement associated with benign prostatic hyperplasia in adult male patients by lowering dihydrotestosterone levels and improving urinary flow.

GNH USA supplies Lestedon as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to EU quality standards and providing reliable sourcing for regulated markets.

Dutasteride is used to treat conditions related to prostate enlargement and androgen‑dependent processes.

Benign prostatic hyperplasia: reduces prostate volume and improves urinary flow. Lower urinary tract symptoms due to BPH: decreases frequency, urgency and nocturia. Prostate enlargement in men with BPH: helps prevent disease progression.

Dutasteride may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Decreased libido - Erectile dysfunction - Ejaculation disorders (e.g., reduced volume) - Breast tenderness or enlargement

Serious or Rare Side Effects: - Severe allergic reaction (rash, angioedema, anaphylaxis) - Significant liver enzyme elevation or hepatitis - Testicular pain or swelling

Before initiating therapy, consider the following safety measures.

Pregnancy: contraindicated (Category X) – may cause fetal abnormalities. Breastfeeding: not recommended – drug is excreted in milk. Prostate cancer: avoid use – may affect disease progression. Liver impairment: use with caution – monitor hepatic function. Drug interactions: review concomitant medications, especially CYP3A4 modulators. Store at ambient temperature: keep below 25°C, in the original pack, and protect from moisture.

Dutasteride can interact with several medicines; awareness helps maintain efficacy and safety.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase dutasteride plasma levels. - Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce dutasteride effectiveness.

Moderate Interactions (Monitor Closely): - Anticoagulants (e.g., warfarin): may enhance bleeding risk. - Alpha‑blockers (e.g., tamsulosin): may increase hypotensive effects. - Finasteride: concurrent use may raise the likelihood of adverse events.