GNH USA

Europe — EMA

Lesine (Drospirenone, Ethinylestradiol)

GNH USA supplies Lesine (Drospirenone/Ethinylestradiol), a combined estrogen‑progestogen oral contraceptive for contraception and menstrual cycle regulation.

Drospirenone, Ethinylestradiol

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What is Drospirenone, Ethinylestradiol?

Drospirenone and Ethinylestradiol, the active ingredients in Lesine, are a combined estrogen‑progestogen oral contraceptive presented as an oral tablet for oral use. It prevents pregnancy and helps regulate menstrual cycles in women of reproductive age by inhibiting ovulation, altering cervical mucus, and modifying the endometrial lining. The formulation is approved in the European Union and is prescribed by healthcare professionals for reliable contraception and cycle management.

GNH USA supplies Lesine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Drospirenone, Ethinylestradiol used for?

Lesine, a combined estrogen‑progestogen oral contraceptive, is indicated for the following therapeutic areas.

Contraception: provides reliable prevention of pregnancy in women of child‑bearing potential. Menstrual cycle regulation: helps achieve more predictable menstrual bleeding patterns. Dysmenorrhea management: reduces menstrual pain and associated symptoms.

What are the side effects of Drospirenone, Ethinylestradiol?

Like all combined oral contraceptives, Lesine may cause a range of adverse reactions.

Common Side Effects: - Nausea - Headache - Breast tenderness - Spotting between periods

Serious or Rare Side Effects: - Deep vein thrombosis - Pulmonary embolism - Stroke - Severe allergic reaction (anaphylaxis)

What precautions apply to Drospirenone, Ethinylestradiol?

Before prescribing Lesine, clinicians should consider the following precautions and warnings. - Pregnancy contraindication: not to be used during pregnancy (Category X). - Smoking in women over 35: increased cardiovascular risk. - History of thromboembolic disorders: avoid use. - Uncontrolled hypertension: contraindicated. - Liver disease: use with caution. - Store at ambient temperature: keep in original packaging, protect from moisture.

What does Drospirenone, Ethinylestradiol interact with?

Lesine can interact with other medicines, altering its effectiveness or safety.

Major Interactions (Avoid): - Enzyme‑inducing anticonvulsants (e.g., carbamazepine, phenytoin) - Rifampin antibiotic - St. John’s Wort herbal supplement

Moderate Interactions (Monitor Closely): - Antifungal ketoconazole - Protease‑inhibitor antiretrovirals

Frequently asked questions

What is Lesine used for?+
Lesine is a combined oral contraceptive containing drospirenone and ethinylestradiol. It is prescribed to prevent pregnancy and to help regulate menstrual cycles in women of reproductive age. It may also be used to manage dysmenorrhea and provide more predictable bleeding patterns.
How does drospirenone/ethinylestradiol work?+
The combination works by suppressing the mid‑cycle surge of luteinizing hormone, thereby inhibiting ovulation. Drospirenone also provides progestogenic activity that thickens cervical mucus, making it hostile to sperm, while ethinylestradiol stabilizes the endometrial lining, reducing breakthrough bleeding.
What is the usual dose of Lesine?+
The dosage regimen of Lesine is determined by the prescribing healthcare professional. Typically, it is taken as one tablet daily for a 21‑day active phase followed by a hormone‑free interval, but the exact schedule and any variations are set by the prescriber based on individual patient needs.
Is Lesine safe to use during pregnancy or breastfeeding?+
Lesine is classified as pregnancy category X, meaning it must not be used during pregnancy because it can harm the fetus. While limited data exist for breastfeeding, combined oral contraceptives are generally considered compatible with lactation; however, a clinician should evaluate the risk‑benefit profile for each mother.
How do I order Lesine from GNH USA?+
To place an order, submit an enquiry on the Lesine product page at gnh-usa.com, specifying the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the team provides pricing, availability, shipping details and any necessary import documentation.
How does Lesine compare with other combined oral contraceptives?+
Lesine contains drospirenone, a progestogen with anti‑mineralocorticoid activity, which may reduce water retention compared with older progestins. Its estrogen component, ethinylestradiol, is standard across many combined pills. Clinicians may choose Lesine for patients who desire a lower risk of bloating or who need a specific hormonal profile, while efficacy in preventing pregnancy remains comparable.
How should Lesine be stored and handled?+
Lesine tablets should be stored at ambient temperature, below 25 °C, in the original blister pack or bottle to protect them from moisture and light. Keep the medication out of reach of children and do not use if the packaging is damaged or the tablets appear discolored.
How is Lesine administered?+
Lesine is taken orally, usually once each day at the same time, with or without food. Patients should swallow the tablet whole and continue the daily regimen for the prescribed cycle, typically 21 active tablets followed by a hormone‑free interval, unless directed otherwise by their healthcare provider.
What are the most serious risks associated with Lesine?+
The most serious risks include thromboembolic events such as deep‑vein thrombosis, pulmonary embolism, stroke, and myocardial infarction, especially in women who smoke, are over 35, or have pre‑existing risk factors. Other severe concerns are severe allergic reactions and liver disease; patients should be monitored closely for any signs of these conditions.
Who should not use Lesine?+
Lesine is contraindicated in women who are pregnant or breastfeeding, have a history of thromboembolic disorders, uncontrolled hypertension, severe liver disease, or known hypersensitivity to drospirenone, ethinylestradiol or any tablet components. Additionally, smokers over 35 years of age should avoid using combined oral contraceptives due to heightened cardiovascular risk.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Drospirenone, Ethinylestradiol
Route
Oral Use
Manufacturer
Theramex Ireland Limited
Origin
EU

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