Lescol Xl

Fluvastatin Sodium, the active ingredient in Lescol Xl, is a HMG‑CoA reductase inhibitor presented as a tablet for oral use. It lowers elevated cholesterol levels and is used in adults at risk of cardiovascular disease.

GNH USA supplies Lescol Xl as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Lescol Xl is a statin that acts on cholesterol metabolism to manage lipid disorders and reduce cardiovascular risk.

Hypercholesterolemia: reduces low‑density lipoprotein (LDL) cholesterol and total cholesterol levels. Primary familial hypercholesterolemia: helps achieve target lipid levels in genetically predisposed patients. Cardiovascular disease prevention: lowers the risk of myocardial infarction and stroke in patients with elevated cholesterol.

Common Side Effects: - Headache: mild to moderate intensity. - Nausea: occasional gastrointestinal upset. - Abdominal pain: discomfort in the stomach area. - Myalgia: muscle aches without weakness. - Diarrhoea: loose stools. - Elevated liver enzymes: mild transaminase increase.

Serious or Rare Side Effects: - Rhabdomyolysis: severe muscle breakdown with risk of renal failure. - Acute liver injury: marked elevation of hepatic enzymes or jaundice. - Severe allergic reaction: rash, angioedema, or anaphylaxis. - Myopathy with weakness: significant muscle weakness. - Acute renal failure: secondary to muscle breakdown products. - Hepatotoxicity: liver dysfunction requiring discontinuation.

Before initiating therapy, consider patient‑specific factors and monitor appropriately. - Liver function monitoring: obtain baseline and periodic liver enzyme tests. - Renal impairment: adjust therapy in patients with reduced kidney function. - Drug interactions: review concomitant medications that affect statin metabolism. - Pregnancy and lactation: avoid use unless benefits outweigh potential risks. - Elderly patients: start with the lowest effective dose and monitor closely. - Store at ambient temperature (below 25°C): keep in the original container, protect from moisture and light.

Fluvastatin may interact with several medicines; assess the interaction potential before prescribing.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., itraconazole, clarithromycin): may increase fluvastatin exposure. - Gemfibrozil: markedly raises risk of myopathy. - Cyclosporine: enhances statin plasma concentrations. - High‑dose niacin: increases risk of hepatotoxicity. - Certain antiretrovirals (e.g., protease inhibitors): elevate statin levels.

Moderate Interactions (Monitor Closely): - Other statins: cumulative risk of muscle toxicity. - Warfarin: may potentiate anticoagulant effect. - Digoxin: possible increase in serum digoxin. - Macrolide antibiotics (e.g., erythromycin): modest increase in statin levels. - Fibrates (except gemfibrozil): monitor for muscle symptoms.