Lesamor (Hydrochlorothiazide, Telmisartan)

Hydrochlorothiazide and Telmisartan, the active ingredients in Lesamor, are a thiazide diuretic and an angiotensin II receptor blocker presented as oral tablets for oral use. The combination is indicated for the management of hypertension in adult patients, helping to lower elevated blood pressure. It lowers blood pressure through complementary mechanisms that reduce vascular resistance and fluid volume.

GNH USA supplies Lesamor as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide with a focus on quality assurance and regulatory compliance.

Lesamor, a combination antihypertensive tablet, acts on the renin‑angiotensin system and renal sodium handling to control high blood pressure. - Primary (essential) hypertension: lowers systolic and diastolic pressure in newly diagnosed patients. - Secondary hypertension: assists in blood pressure control when hypertension is due to renal or endocrine causes. - Hypertensive patients with fluid retention: provides a diuretic effect that reduces plasma volume and aids pressure reduction.

Common Side Effects: - Dizziness or light‑headedness - Headache - Fatigue - Increased urination - Electrolyte disturbances (e.g., low potassium) - Mild gastrointestinal upset

Serious or Rare Side Effects: - Severe hypotension - Acute kidney injury - Hyperkalemia - Allergic reactions such as rash or angioedema - Liver enzyme elevations - Blood disorders (e.g., leukopenia, thrombocytopenia)

Before initiating therapy, consider patient history and concomitant conditions. - Renal impairment: monitor kidney function and electrolytes. - Hepatic disease: use with caution and assess liver enzymes. - Electrolyte imbalance: check serum potassium and sodium regularly. - Concomitant antihypertensives: watch for additive blood‑pressure lowering effects. - Pregnancy and lactation: avoid unless clearly indicated by a physician. - Store at ambient temperature: keep below 25°C in the original packaging, protect from moisture and light.

Potential drug‑drug interactions may affect efficacy or safety. Major Interactions (Avoid): - Potassium‑sparing diuretics or supplements: risk of hyperkalemia. - Lithium: increased lithium levels may cause toxicity. - ACE inhibitors or other ARBs: additive hypotensive effect. - NSAIDs: may reduce antihypertensive efficacy and impair renal function.

Moderate Interactions (Monitor Closely): - Antidiabetic agents: diuretic may affect glucose control. - Digoxin: altered serum concentrations. - Corticosteroids: may increase sodium retention. - Antidepressants (e.g., SSRIs): monitor for hyponatremia. - Alcohol: can enhance hypotensive effect.