GNH USA

Europe — EMA

Lercanidipine Hcl Recordati Industria Chimica E Farmaceutica S.P.A. (Lercanidipine Hydrochloride)

GNH USA supplies Lercanidipine Hcl Recordati Industria Chimica E Farmaceutica S.P.A. (Lercanidipine), a calcium channel blocker for hypertension.

Lercanidipine Hydrochloride

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What is Lercanidipine Hydrochloride?

Lercanidipine, the active ingredient in Lercanidipine Hcl Recordati Industria Chimica E Farmaceutica S.P.A., is a calcium channel blocker presented as an oral tablet for oral use. It treats hypertension in adult patients by relaxing vascular smooth muscle and lowering blood pressure.

GNH USA supplies Lercanidipine Hcl Recordati Industria Chimica E Farmaceutica S.P.A. as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Lercanidipine Hydrochloride used for?

Lercanidipine is a dihydropyridine calcium‑channel blocker used in the management of high blood pressure conditions.

- Essential hypertension: reduces systolic and diastolic blood pressure to target levels. - Isolated systolic hypertension: lowers elevated systolic pressure, especially in older adults. - Cardiovascular risk management: contributes to overall risk reduction by maintaining controlled blood pressure.

What are the side effects of Lercanidipine Hydrochloride?

Lercanidipine may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects: - Headache: mild to moderate intensity. - Flushing: sensation of warmth and redness. - Peripheral edema: swelling of ankles or feet. - Dizziness or light‑headedness, especially after standing. - Tachycardia: increased heart rate. - Nasal congestion.

Serious or Rare Side Effects: - Severe hypotension: marked drop in blood pressure. - Angioedema: swelling of face, lips, or throat. - Myocardial infarction: rare but reported. - Hepatic enzyme elevation. - Severe skin reactions such as Stevens‑Johnson syndrome. - Arrhythmias: abnormal heart rhythms.

What precautions apply to Lercanidipine Hydrochloride?

Before initiating therapy with lercanidipine, several safety considerations should be observed.

- Blood pressure monitoring: ensure adequate control and avoid excessive drops. - Hepatic impairment: dose adjustment may be required in patients with liver dysfunction. - Elderly patients: start at the lowest effective dose and monitor closely. - Concomitant antihypertensives: watch for additive hypotensive effects. - Pregnancy and lactation: safety not established; avoid unless clearly needed. - Store at ambient temperature: keep in the original container, protect from moisture and light.

What does Lercanidipine Hydrochloride interact with?

Lercanidipine can interact with several drug classes, influencing its efficacy and safety profile.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin): may increase plasma levels. - Grapefruit juice: can markedly raise drug concentration. - Other potent vasodilators: risk of severe hypotension.

Moderate Interactions (Monitor Closely):\n- Diuretics: may enhance antihypertensive effect. - Beta‑blockers: additive blood pressure lowering. - Other calcium‑channel blockers: potential for cumulative cardiovascular effects. - NSAIDs: may blunt antihypertensive response. - Digoxin: monitor for altered serum levels.

Frequently asked questions

What is Lercanidipine used for?+
Lercanidipine is prescribed to lower high blood pressure (hypertension). By relaxing the smooth muscle in arterial walls, it helps achieve target blood pressure levels and reduces the risk of cardiovascular complications associated with uncontrolled hypertension.
How does Lercanidipine work?+
Lercanidipine blocks L‑type calcium channels in vascular smooth muscle cells. This inhibition reduces calcium entry, leading to vasodilation of peripheral arteries, decreased vascular resistance, and ultimately a reduction in systemic blood pressure.
What is the usual dose of Lercanidipine?+
The appropriate dose of Lercanidipine is determined by a qualified prescriber based on the individual’s clinical condition, response, and any concomitant medications. Patients should follow the dosing instructions provided by their healthcare professional.
Is Lercanidipine safe during pregnancy or breastfeeding?+
Safety of Lercanidipine in pregnancy and lactation has not been established. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and only under direct medical supervision.
How do I order Lercanidipine Hcl Recordati from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.
How does Lercanidipine compare with other antihypertensive classes?+
Lercanidipine belongs to the dihydropyridine calcium‑channel blocker class, offering potent arterial vasodilation with a relatively low incidence of reflex tachycardia. Compared with ACE inhibitors or ARBs, it primarily targets vascular tone rather than the renin‑angiotensin system, making it useful as monotherapy or in combination regimens.
What are the storage and handling requirements for Lercanidipine?+
Lercanidipine tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect from moisture and light. Keep the product out of reach of children and avoid exposure to extreme temperatures.
How is Lercanidipine administered?+
Lercanidipine is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with a glass of water and not chewed or crushed, unless otherwise directed by a healthcare professional.
What are the most serious risks associated with Lercanidipine?+
Serious adverse events, though rare, include severe hypotension, angioedema, myocardial infarction, and significant liver enzyme elevations. Patients should seek immediate medical attention if they experience sudden swelling, chest pain, fainting, or marked drops in blood pressure.
Who should not use Lercanidipine?+
Lercanidipine is contraindicated in patients with known hypersensitivity to the drug or any component of the formulation, and in individuals with severe aortic stenosis or cardiogenic shock. Caution is also advised for patients with significant hepatic impairment.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Lercanidipine Hydrochloride
Route
Oral Use
Manufacturer
Recordati Industria Chimica E Farmaceutica S.P.A.
Origin
EU

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