Lentocilin S 2400

Benzathine benzylpenicillin, the active ingredient in Lentocilin S 2400, is a penicillin (beta‑lactam antibiotic) presented as an injectable solution for intramuscular use. It treats streptococcal infections, syphilis, rheumatic fever prophylaxis and other bacterial infections susceptible to penicillin in appropriate patients.

GNH USA supplies Lentocilin S 2400 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Lentocilin S 2400 is a penicillin antibiotic used to treat bacterial infections that are sensitive to beta‑lactam agents. - Streptococcal infections: provides rapid bactericidal therapy to resolve throat, skin and invasive streptococcal disease. - Syphilis: eradicates Treponema pallidum, achieving cure in early and late stages when administered appropriately. - Rheumatic fever prophylaxis: prevents recurrence of rheumatic fever by maintaining adequate serum penicillin levels. - Other susceptible bacterial infections: treats infections caused by penicillin‑sensitive organisms such as certain staphylococci and pneumococci.

Adverse reactions may vary in frequency and severity.

Common Side Effects: - Injection site pain: mild to moderate discomfort at the injection site. - Erythema: localized redness around the injection area. - Fever: low‑grade temperature elevation. - Nausea: transient upset stomach. - Diarrhea: mild gastrointestinal upset. - Headache: occasional tension‑type headache.

Serious or Rare Side Effects: - Anaphylaxis: severe, potentially life‑threatening allergic reaction. - Serum sickness: immune complex‑mediated fever, rash and arthralgia. - Stevens‑Johnson syndrome: severe mucocutaneous blistering. - Clostridioides difficile‑associated diarrhea: severe colitis after disruption of gut flora. - Hemolytic anemia: immune‑mediated destruction of red blood cells. - Severe allergic reactions: including angioedema and bronchospasm.

Before using Lentocilin S 2400, consider the following safety measures. - Allergy assessment: confirm no history of severe penicillin allergy. - Renal impairment: adjust use in patients with reduced kidney function. - Hepatic disease: monitor liver function in patients with liver disorders. - Pregnancy and lactation: safety category unknown; weigh benefits against potential risks. - Concomitant medications: review for possible interactions that may affect efficacy or safety. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Benzathine benzylpenicillin may interact with other medicines; monitor accordingly.

Major Interactions (Avoid): - Methotrexate: increased toxicity risk. - Live vaccines: reduced vaccine efficacy and possible infection. - Oral contraceptives: decreased hormonal effectiveness.

Moderate Interactions (Monitor Closely): - Aminoglycosides: possible antagonistic effect reducing bacterial killing. - Tetracyclines: may diminish penicillin activity. - Warfarin: potential alteration of INR, requiring closer coagulation monitoring.