Lentocilin S 1200

Benzathine benzylpenicillin, the active ingredient in Lentocilin S 1200, is a penicillin (beta‑lactam antibiotic) presented as an intramuscular injection for use in bacterial infections. It is employed to treat susceptible streptococcal infections, syphilis and to prevent rheumatic fever in patients requiring long‑acting penicillin therapy.

GNH USA supplies Lentocilin S 1200 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Lentocilin S 1200 is a long‑acting penicillin used to treat infections caused by penicillin‑sensitive bacteria. - Streptococcal infections: eradicates susceptible streptococci and resolves symptoms. - Syphilis (early and late stages): provides sustained bactericidal concentrations to cure infection. - Prophylaxis of rheumatic fever: prevents recurrence after a streptococcal episode. - Other penicillin‑sensitive infections: treats a range of bacterial diseases responsive to benzathine penicillin.

Common Side Effects: - Pain or swelling at the injection site. - Mild rash or itching. - Low‑grade fever. - Nausea.

Serious or Rare Side Effects: - Anaphylactic reaction: difficulty breathing, hypotension, urticaria. - Severe neutropenia or agranulocytosis. - Serum sickness‑like reaction: fever, arthralgia, rash. - Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Acute hemolytic anemia in susceptible individuals.

Before administering Lentocilin S 1200, consider the following precautions. - Allergy assessment: confirm no known hypersensitivity to penicillins. - Renal function: evaluate in patients with impaired kidney function. - Pregnancy: use only when benefits outweigh potential risks. - Concurrent antibiotics: avoid overlapping beta‑lactam therapy unless indicated. - Administration technique: inject deep intramuscularly, rotate sites to reduce tissue injury. - Store at ambient temperature: keep in original packaging, protect from moisture and light.

Lentocilin S 1200 may interact with several medicines; monitor patients accordingly. Major Interactions (Avoid): - Methotrexate: increased toxicity risk. - Oral anticoagulants (e.g., warfarin): heightened bleeding tendency. - Live vaccines: reduced efficacy of immunisation. Moderate Interactions (Monitor Closely): - Allopurinol: possible rash enhancement. - Oral contraceptives: decreased hormonal effectiveness. - Probenecid: may raise penicillin plasma levels, requiring dose adjustment.