Lendorm

Brotizolam, the active ingredient in Lendorm, is a benzodiazepine presented as a tablet for oral use. It is indicated for the short‑term treatment of insomnia in adults.

GNH USA supplies Lendorm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Brotizolam acts on the central nervous system to facilitate sleep in patients with insomnia. - Insomnia (sleep initiation): helps patients fall asleep more quickly. - Insomnia (sleep maintenance): reduces the number of nighttime awakenings. - Insomnia associated with anxiety: promotes restful sleep despite underlying anxiety.

Brotizolam may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Drowsiness: feeling unusually sleepy during the day. - Dizziness: light‑headed sensation, especially when standing quickly. - Headache: mild to moderate pain in the head. - Fatigue: reduced energy and motivation. - Amnesia: difficulty recalling events after taking the medication. - Muscle weakness: reduced strength in limbs.

Serious or Rare Side Effects: - Respiratory depression: slowed or shallow breathing, especially with other depressants. - Dependence or withdrawal syndrome: difficulty stopping the drug after prolonged use. - Severe allergic reactions: rash, swelling, or difficulty breathing. - Paradoxical reactions: increased agitation, aggression, or anxiety. - Suicidal thoughts: emergence of depressive or suicidal ideation. - Depression: worsening mood or depressive symptoms.

Before prescribing Brotizolam, clinicians should consider several safety factors. - Assess renal and hepatic function: adjust use if impairment is present. - Avoid abrupt discontinuation: taper the dose to prevent withdrawal. - Use caution in elderly patients: increased sensitivity to sedative effects. - Advise against operating machinery or driving: impairment may persist. - Contraindicated in patients with known hypersensitivity to benzodiazepines. - Store at ambient temperature: keep in the original container, protect from moisture.

Brotizolam can interact with other substances that affect the central nervous system or its metabolism.

Major Interactions (Avoid): - Alcohol: additive sedation and respiratory depression. - Other CNS depressants (opioids, barbiturates): heightened sedative effect. - CYP3A4 inhibitors (ketoconazole, erythromycin): increased plasma concentrations.

Moderate Interactions (Monitor Closely): - CYP3A4 inducers (rifampin, carbamazepine): reduced efficacy. - Antihistamines: possible enhanced drowsiness. - Antihypertensives: potential additive hypotensive effect.