GNH USA

Europe — EMA

Lenalidomide Stada

GNH USA supplies Lenalidomide Stada (Lenalidomide), an immunomodulatory agent for multiple myeloma and mantle cell lymphoma. Request a quote for supply.

Lenalidomide

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What is Lenalidomide?

Lenalidomide, the active ingredient in Lenalidomide Stada, is an immunomodulatory drug (IMiD) presented as an oral tablet for oral use. It is indicated for the treatment of multiple myeloma, myelodysplastic syndromes, and mantle cell lymphoma in adult patients.

GNH USA supplies Lenalidomide Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide. The company adheres to stringent quality standards and regulatory requirements to ensure product integrity.

What is Lenalidomide used for?

Lenalidomide is an immunomodulatory agent used in hematologic malignancies.

- Multiple Myeloma: improves progression‑free survival and overall response rates in adult patients. - Myelodysplastic Syndromes: reduces transfusion dependence and delays progression to acute leukemia. - Mantle Cell Lymphoma: enhances response rates when combined with standard chemotherapy in adult patients.

What are the side effects of Lenalidomide?

Lenalidomide may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Neutropenia: reduced neutrophil count. - Thrombocytopenia: low platelet levels. - Fatigue: persistent tiredness. - Diarrhea: loose stools.

Serious or Rare Side Effects: - Venous thromboembolism: blood clots in veins. - Severe neutropenia: markedly low neutrophils increasing infection risk. - Embryo‑fetal toxicity: severe risk of birth defects.

What precautions apply to Lenalidomide?

When using Lenalidomide, careful monitoring and specific precautions are required.

- Pregnancy: contraindicated (Category X) due to high risk of fetal malformations. - Thromboembolic risk: assess and consider prophylactic anticoagulation. - Hematologic monitoring: regular CBC to detect neutropenia, thrombocytopenia, anemia. - Renal impairment: dose adjustment may be required; monitor renal function. - Drug interactions: avoid concomitant use with strong CYP inducers without supervision. - Store at ambient temperature: keep below 25 °C, protect from moisture and light in original container.

What does Lenalidomide interact with?

Lenalidomide interacts with several drug classes; awareness of interaction severity guides clinical decisions.

Major Interactions (Avoid): - Strong CYP3A4 inducers (e.g., rifampin): may reduce lenalidomide exposure. - Anticoagulants (e.g., warfarin): increased bleeding risk. - Live vaccines: heightened risk of infection.

Moderate Interactions (Monitor Closely): - CYP3A4 inhibitors (e.g., ketoconazole): may increase lenalidomide levels. - Immunosuppressants (e.g., cyclosporine): may enhance toxicity. - NSAIDs: may increase risk of thrombosis.

Frequently asked questions

What conditions is Lenalidomide Stada used to treat?+
Lenalidomide Stada is prescribed for adult patients with multiple myeloma, myelodysplastic syndromes, and mantle cell lymphoma. In each of these hematologic cancers, the drug helps to control disease progression, improve response rates, and reduce the need for blood transfusions where applicable.
How does lenalidomide work at the molecular level?+
Lenalidomide binds to cereblon, a component of the CRL4‑cereblon E3 ubiquitin ligase complex. This binding triggers the ubiquitination and proteasomal degradation of transcription factors Ikaros and Aiolos, leading to altered cytokine production, enhanced immune cell activity, and inhibition of new blood‑vessel formation, all of which contribute to its anti‑cancer effects.
What is the usual dosing regimen for Lenalidomide Stada?+
The specific dose and schedule of Lenalidomide Stada are determined by the prescribing clinician based on the patient’s diagnosis, disease stage, renal function, and prior therapies. Healthcare providers tailor the regimen to achieve optimal efficacy while managing safety, and patients should follow the prescriber’s instructions exactly.
Is Lenalidomide Stada safe to use during pregnancy or while breastfeeding?+
Lenalidomide Stada is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy because it can cause severe fetal malformations or death. It is also not recommended for breastfeeding mothers, as the drug can be excreted in breast milk and may harm the infant.
How do I order Lenalidomide Stada from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.
How does Lenalidomide compare with other treatments for multiple myeloma?+
Lenalidomide belongs to the immunomodulatory drug class, offering a distinct mechanism of action compared with proteasome inhibitors or monoclonal antibodies. It is often used in combination regimens to enhance response rates and prolong progression‑free survival, providing an oral alternative that can be integrated into existing treatment protocols.
What are the recommended storage conditions for Lenalidomide Stada?+
Lenalidomide Stada should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keeping the product in a dry, cool place helps maintain its stability and potency throughout its shelf life.
How is Lenalidomide Stada administered to patients?+
Lenalidomide Stada is taken orally, usually as a tablet swallowed with water. The exact timing (e.g., with or without food) and frequency are dictated by the prescribing physician’s regimen, and patients should adhere strictly to the prescribed schedule to ensure consistent drug exposure.
What are the most serious risks associated with Lenalidomide Stada?+
The most serious risks include severe neutropenia, which can predispose patients to life‑threatening infections, venous thromboembolism (blood clots), and embryo‑fetal toxicity leading to birth defects. Patients should be monitored closely for signs of infection, clotting, and any pregnancy‑related concerns.
Who should not use Lenalidomide Stada?+
Lenalidomide Stada should not be used by pregnant women, individuals planning to become pregnant, or nursing mothers. It is also contraindicated in patients with known hypersensitivity to lenalidomide or any of its excipients, and caution is advised in those with severe renal impairment or uncontrolled thrombotic risk.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Lenalidomide
Route
Oral Use
Manufacturer
Stada Arzneimittel Ag
Origin
EU

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